A MAJOR ADVANCE

Scientists in Britain have made a major leap forward in efforts to treat blindness.

They have grown part of an eye in the laboratory and have extracted the light-sensitive cells which are the key to vision.

These cells were injected into mice, where they seemed to grow normally and formed the crucial connections between the eye and brain.

Such developments could pave the way for a treatment which could eventually give millions back their sight. It is hoped the first human patients could be treated in as little as five years. Transplanting just a small number of cells could have a big impact on quality of life.

Those who could benefit include men and women with age-related macular degeneration – the most common cause of blindness in the elderly. This condition affects more than 600,000 Britons and the number is expected to triple in the next 25 years as the elderly population swells.

There are few treatments for the condition – and no cure.

The research and experimentation is being carried out at University College London in which scientists are trying to replace damaged cells in the retina, the light sensitive ‘film’ at the back of the eye.

Last year, researchers used healthy cells from young mice to restore vision in adult animals. The results were said to be ‘dramatic’, with the treated animals able to quickly find their way out of a miniature swimming pool in dim light, while untreated ones swam around in circles.

The project’s lead-scientist, Professor Robin Ali, said the results amount to a ‘major advance’. His team took embryonic stem cells – ‘master cells’ capable of turning into other cell types and widely touted as a repair kit for the body – and used a cocktail of nutrients to coax them into turning into a retina.

They then raided the laboratory-grown retina for rods (key cells which pick up light and send it to the brain for conversion into images). The rods were then transplanted into the eyes of mice.

A retina has been grown in a dish before but Professor Ali’s team are the first to transplant cells from one successfully.

The journal Nature Biotechnology was the first to report the findings and has said that the lab-grown cells integrated into the existing eye was successful in forming the nerve connections needed to send information to the brain.

Professor Ali said:

… We are getting closer and closer to carrying out a trial.

However, the need to be highly confident that the treatment is safe and effective means that widespread use is at least 10-15 years away.

The Medical Research Council, which funded the team’s work, said in a statement:

… This study is an important milestone on the road to developing a widely available cell therapy for blindness.