Health, Medical, Research, Science

Liver grown in the laboratory raises real hope…

AN ALTERNATIVE TO TRANSPLANTS

Scientists have grown a tiny liver in experiments which has been hailed as ‘a huge step forward’ for desperately ill patients waiting for a transplant.

The technique that creates man-made tissue could be used to repair diseased and damaged organs – and one day end the agonising and sometimes hopeless wait for a donor.

These advances could also be used to test new medicines, ending the need for risky tests on humans, and to grow tissue for new kidneys, lungs and pancreases.

British scientists have welcomed the research in Japan as holding out ‘promise’ for an alternative to transplants.

More than 7,000 Britons are on the waiting list, including 154 children. Most need kidneys but nearly 500 need a liver and around 250 are waiting for healthy lungs.

Researchers used the three types of cell which generate the liver in a human embryo to grow a tiny piece of tissue in a dish.

It was grafted on to a mouse’s brain, where it linked up to the blood supply and could be monitored as it grew for at least two months. The tissue had many features of a human liver, including the ability to break down drugs.

It also extended the life of rodents with fatal liver disease. The findings were reported in the journal Nature.

Researcher Takanori Takebe said growing patches of liver holds ‘enormous therapeutic potential’.

Dr Dusko Ilic, a stem cell scientist from King’s College London, said: ‘The strategy is very promising and a huge step forward.’

Dr Mathew Smalley, of Cardiff University, said the technique may not be suitable for all transplant patients but still had ‘real promise’.

NHS Blood and Transplant, which is responsible for running the organ donor register, said the research was ‘very exciting’.

But it could take many years to offer ‘widespread, readily-available treatment’, the NHS body said. In the meantime, more organ donors are still needed to cut the number of patients who die waiting for a transplant.

It is hoped the first tests on people could start in a decade.

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Egypt, Foreign Affairs, Government, Society, United States

Morsi ousted by military in Egypt…

Gen Abdul Fattah al-Sisi said Mr Morsi had failed to meet demands for national unity. Despite Egyptian President Mohammed Morsi's insistence he would remain in power, the country's army chief has announced that Morsi is being replaced by the chief justice of the constitutional court. The military chief added that he has suspended the Islamist-backed constitution and announced that a new Cabinet will be formed.

Gen Abdul Fattah al-Sisi said Mr Morsi had failed to meet demands for national unity. Despite Egyptian President Mohammed Morsi’s insistence he would remain in power, the country’s army chief has announced that Morsi is being replaced by the chief justice of the constitutional court. The military chief added that he has suspended the Islamist-backed constitution and announced that a new Cabinet will be formed.

MORSI REMOVED

Egypt’s military have deposed the country’s first democratically elected president, installing the head of the country’s highest court as an interim leader.

General Abdel-Fatah El-Sisi of the Egyptian Army said the military was fulfilling its ‘historic responsibility’ to protect the country by ousting Mohamed Morsi, the Western-educated Islamist leader elected a year ago. The country’s constitution has been suspended and new parliamentary elections will be held. The head of the country’s Supreme Constitutional Court, Adly Mansour, will replace Mr Morsi.

Mansour will have the power to issue constitutional declarations during the interim period and is charged with establishing a government that is ‘strong and diverse’. El-Sisi said that Morsi ‘did not achieve the goals of the people’ and failed to meet the demands of the generals by sharing power with his opposition.

The announcement was met with jubilation and fireworks by opponents who packed Tahrir Square, now the epicentre of two Egyptian revolts.

The Muslim Brotherhood, the long-suppressed Islamist movement whose political arm Mr Morsi led as a candidate, said the coup ‘wastes the will of the people and returns Egypt to tyranny.’

Before last night’s announcement, troops moved into key positions around the capital, closing off a bridge over the Nile River and surrounded supporters of Mr Morsi who had descended onto Rabaa Adawya Square.

Morsi, a U.S.-educated religious conservative, was elected president in June 2012. His approval ratings, though, have plummeted as his government has failed to keep order or revive Egypt’s economy. The chaos and anarchy, including open sexual assaults on women in Egypt’s streets, has driven away tourists and investors, while opponents say Morsi’s rule was becoming increasingly authoritarian.

Mohamed ElBaradei, the former head of the International Atomic Energy Agency (IAEA) and a leading opposition figure, said Mr Morsi’s removal was a ‘correction for the way of the revolution’ that drove Egypt’s former leader Hosni Mubarak from office in 2011.

Mr ElBaradei says that by having early presidential elections will allow Egyptians to build together by agreeing on a democratic constitution. This, he says, will guarantee the country’s freedoms.

The Egyptian military dominated the country for more than six decades and took direct control for 18-months after Mubarak was deposed. Following a previous demand that Morsi offer concessions to the opposition, it gave him 48 hours at the start of this week to order reforms.

As the ultimatum deadline approached, Morsi offered to form an interim coalition government to oversee parliamentary elections and revise the constitution that was enacted in January.

But shortly after the deadline, an aide to Mr Morsi, Essam El Haddad, said that a coup was underway and warned that the generals risked bloodshed by moving against Morsi.

Others, however, such as Naguib Abadeer, a member of the opposition Free Egyptians Party, said what was under way was ‘not by any means a military coup’ but more of a ‘revolution’. Some have even said Morsi has been beaten by mob rule.

Morsi lost his legitimacy in November, when he declared courts could not review his decrees and ousted the country’s prosecutor-general. And concerns were raised that the Muslim Brotherhood had ‘hijacked the vote of the people’ by running on a religious platform, decrying that elections had not been democratic.

The United States, Egypt’s leading ally, has urged all parties to come to a peaceful resolution to the ‘tense and fast-moving’ situation.

Washington has supplied Egypt’s military with tens of billions in support and equipment spanning more than 30 years. Under U.S. law, that support could be cut off if a coup has materialised, but the State Department has said that a thorough analysis will be required before any decision is made on continued support for Egypt. Washington itself has not described the military takeover as a coup.

Mr Morsi’s government was already crumbling before his departure. Five cabinet ministers had already resigned this week, including Foreign Minister Mohamed Kamel Amr. Former Prosecutor-General Abdel-Meguid Mahmoud will meet today with the Supreme Judicial Council to be re-confirmed in the post. Mahmoud had been ousted following the 2011 revolution through changes that Mr Morsi had made to last November’s constitutional declarations. But Mahmoud’s return will signify a tilt towards Mubrak-era officials over Muslim Brotherhood loyalists.

In addition, 30 members of the Shura Council, the upper house of parliament, have resigned.

Mr Morsi’s numerous and adamant supporters point out that he is the legitimate president and say that opponents seeking to depose him are circumventing the democratic process.

A FRAGILE PEACE

The Muslim Brotherhood Islamists will not take kindly to their government being overthrown by a military style coup just 12-months after it was installed by a popular vote. When Hosni Mubarak was toppled from power in 2011, there was always a danger that the West would cheer on the revolution that might unwittingly have unleashed the forces of radical Islam. So it proved.

Yet, the election last year of a Muslim Brotherhood government should not have come as any great surprise. Mubarak had so dismantled the normal political processes inside Egypt that the only two remaining institutions were the army and the Muslim Brotherhood. The Brotherhood, though effectively banned, had worked away for 80 years at the grass-roots level and was the only party in a position to profit from the country’s move to democracy.

Crucially, however, what President Mohammed Morsi failed to understand was that his electoral victory obliged him to reach out to those who did not support the Brotherhood. Mr Morsi was in a position to claim democratic legitimacy, but only up to a point. As the beneficiary of a revolution, he should have led an inclusive administration that recognised and acknowledged the powerful secular instincts of a large section of Egyptian society.

Instead, what had been witnessed was a country being taken on a journey down the road to an Islamist future that alienated many of those who had been at the forefront of the 2011 uprising. The rights of women were curtailed, sharia law was imposed and the tourists on whom Egypt’s economy relied stayed away.

Last weekend, the people once again poured onto the streets and into Tahrir Square demanding reforms. Morsi’s obduracy dug in further and, with the country on the brink, the military stepped in. Once the generals had issued their ultimatum to Egypt’s political leaders to sort out their differences, Mr Morsi’s fate was unquestionably sealed.

The constitution has now been suspended and new elections will be held to form a government of national unity, which might at least spare Egypt the prospect of a ghastly civil war. We should remember, though, that the last time an army in an Arab country overturned the election of an Islamist government was in Algeria in 1991. That ushered in a decade-long civil war in which some 200,000 people died.

Despite the celebrations on the streets, the potential for serious violence in Egypt cannot be dismissed. The Islamists will not take kindly to their government being removed by military force just a year after it was installed with a popular vote of more than 50 per cent – a legitimacy that no government in Egypt had achieved for generations. Why the Islamists might ask, should they now take the ballot box seriously when their mandate has been overturned by force?

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BBC, Government, National Audit Office

£369m severance payments at the BBC. A probe is possible…

NATIONAL AUDIT OFFICE REPORT

BBC executives who authorised severance payments amounting to £369 million to their own staff may be investigated by the police. The warning came from Conservative MP Rob Wilson who has written to the National Audit Office (NAO) and BBC director-general Lord Hall asking for full disclosure of the names of those responsible. Mr Wilson has promised to take evidence of fraud to the police.

MPs who sit on the influential Public Accounts Committee have called for ‘full accountability’ and castigated the ‘greedy and excessive payments’ paid by a ‘self-serving elite’ at the head of the BBC.

As corporation bosses insisted there was no need for a ‘witch-hunt’, pressure is growing on those responsible to face internal disciplinary action and to meet the full force of the law if any of the deals proved to be fraudulent.

In a report published this week, the NAO found pay-outs were made to 7,500 staff over eight years, including £61 million to 401 senior managers. The report states that the corporation had paid staff more than they were entitled to in almost a quarter of the cases it reviewed, putting ‘public trust at risk’.

It is understood that a £680,400 farewell payment was made to the BBC’s former chief operating officer and a £949,000 payment to another former senior executive.

Evidence will be taken next week before a special hearing of the Public Accounts Committee. Former director-general Mark Thompson, who is cited as being personally involved in several of the biggest deal payoffs, will not attend. Mr Thompson says he has a ‘diary commitment’.

Writing to the NAO’s head, Amyas Morse, Mr Wilson asked whether it had unearthed any evidence of fraud, collusion in fraud, misuse of public funds, or other wrongdoing in relation to severance payments at the BBC in recent years. Mr Wilson says, that, based on the reply received, he will consider whether there are grounds to refer the matter to the police.

The BBC’s newly appointed director of news and current affairs, James Harding, has claimed that licence fee payers did not want the corporation to be ‘apologetic’.

Mr Harding, a former editor of the Times, said:

… The BBC has rightly made its fair share of apologies over the past year. I, both as a licence-fee payer and a future employee don’t want an apologetic BBC, I want an ambitious BBC. You don’t want to be apologetic about the BBC, you want to be ambitious about the BBC, that’s the essential choice.

The BBC’s director of strategy and digital, James Purnell, is the only member of the corporation’s executive committee to have given an interview on severance payments since the NAO report was published.

Mr Purnell, a former Labour minister, appeared on BBC2’s Newsnight programme on Monday evening, and has resisted calls to point the finger of blame at individuals responsible for agreeing the payments. He said:

… It was a collective decision. On things like this you can have a witch-hunt or you can learn from your mistakes and that is exactly what we are going to do.

But Conservative MP, Richard Bacon, who also sits on the public accounts committee said that unless (and until) people are named you will not get accountability. Mr Bacon added:

… At the top of the BBC there is a self-serving elite who just look after themselves. These payments were greedy and excessive.

The NAO report also revealed that the BBC still plans to make 15 further severance payments of more than £150,000, even though Lord Hall is on record as saying that such deals would be scrapped in April. Mr Purnell said it would be illegal to ‘unpick’ them because those involved had been sent letters setting out their severance terms.

Labour MP Margaret Hodge, who chairs the committee, urged Lord hall to scrap the deals. She says he needs to be very firm and should not be allowed to back down on these payments.

The NAO has stressed that it had not found any evidence of illegality during its investigation of severance deals to senior managers.

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