Health, Medical, Research, Science

New biological marker could detect Alzheimer’s disease ten years before symptoms appear…

EARLY TEST FOR DETECTING ALZHEIMER’S

Scientists are hoping that a new test could detect Alzheimer’s disease at least a decade before symptoms appear. That would pave the way for early treatment.

Researchers have discovered that a fall in levels of a certain type of genetic material could signal an increased risk and propensity of developing Alzheimer’s.

The biological markers are found within the cerebral spinal fluid (CSF) some 10 years before signs of dementia become apparent.

There are approximately 800,000 people with dementia in the UK, and current trends suggest that one in three people over 65 will die from the degenerative disease.

Presently, the only accurate method to diagnose the disease is by post-mortem neuropathological analysis, although other functional tests (such as memory and brain tests) can be used to determine whether drugs or other forms of treatment may help.

Researchers at Spain’s CSIC Institute of Biomedical Research of Barcelona believe they may have found a biological marker that could suggest the disease process is underway before symptoms start to appear.

Scientists found a drop in the content of mitochondrial DNA (mtDNA) –genetic material present in the energy centre of cells – in spinal fluid may be a sign for the disease.

They suggest that diminishing mtDNA levels reflect the reduced ability of mitochondria to power brain cells, thus triggering their death.

The drop in the concentration of mtDNA precedes the appearance of other recognised biochemical Alzheimer’s biomarkers, suggesting the process of Alzheimer’s disease starts earlier than previously thought and that mtDNA depletion may be one of the earliest predictors.

Researchers have previously been unable to detect the genetic material in spinal fluid, but they used a new technique to amplify tiny amounts. The research study was first reported in the journal Annals of Neurology.

The researchers at CSIC now hope other labs and hospitals will be able to replicate the results.

They say by finding a way to block the degeneration, clinicians may be able to diagnose and treat the disease before symptoms even appear.

Lead author Dr Ramon Trullas, said:

… If our initial findings can be replicated by other laboratories, the results will change the way we currently think about the causes of Alzheimer’s.

… The discovery of a fall in levels of a certain type of genetic material could signal an increased risk of developing Alzheimer’s.

… This discovery may enable us to search for more effective treatments that can be administered during the pre-clinical stage.

Dr Marie Janson of Alzheimer’s Research UK, the UK’s leading dementia research charity, said:

… Problems with mitochondria have already been linked to Alzheimer’s, which is why Alzheimer’s Research UK is currently funding research to further examine this link.

… This small study suggests that decreased mitochondrial DNA in cerebrospinal fluid may indicate the earliest stages of Alzheimer’s, but more work is needed to confirm this in larger groups of people.

… It would be useful to see further studies investigate changes in mitochondrial DNA over time, to determine how long before symptoms such changes might be detected.

… We know Alzheimer’s begins to develop before symptoms appear, and the ability to detect the disease at this stage is crucial for recruiting the right people for clinical trials of potential new treatments.

 

The discovery of a fall in levels of a certain type of genetic material could signal an increased risk of developing Alzheimer's disease. Image shows a CT scan of the brain of someone with Alzheimer's.

The discovery of a fall in levels of a certain type of genetic material could signal an increased risk of developing Alzheimer’s disease. Image shows a CT scan of the brain of someone with Alzheimer’s.

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Site Note –

EVOLVING SITE/FUTURE DEVELOPMENTS

This site will be evolving shortly to incorporate separate pages for the sciences. As well as traditional scientific matters, other branches of the sciences including information and decision theory, computing and environmental science, amongst others, are intended, over time, to be included.

This site was launched on the 3 June, 2013, and has attracted nearly 37,000 visitors to the Home Page. Visitors have been from all over the world. My thanks go to WordPress.com who provide excellent blogging and publishing tools, organisations that have advertised my work and to the many visitors to the site.

The ‘Home Page’ will remain categorised as Arts, Reviews and Current Affairs, with new pages concerning the sciences being gradually incorporated.

15 August 2013

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Economic, Government, Politics, Russia, Society, United States

Bilateral relations between America and Russia…

RUSSIA ISN’T WHAT IT ONCE WAS

At the pinnacle of the Cold War, leaders from both Russia and America would meet on fairly equal terms to bargain over the fate of the world. If either titan refused to meet the other, that generally signalled a cast chill over humanity.

Yet, the idea that Barack Obama and Vladimir Putin remain genuine peers today is a delusion and remnant left over from the era of superpower confrontation. For all the bombastic rhetoric emanating from the Kremlin, the inescapable reality is that America possesses a widening advantage over Russia on every possible measure of national power: from economic strength to its military might.

The decision by Mr Obama to cancel a proposed summit with Mr Putin in Moscow next month, ostensibly because of the furore surrounding Russia’s decision to grant the US fugitive and whistleblower Edward Snowden asylum status, was both inevitable and eminently sensible. Washington’s justified response to the posturing of a weaker rival was credible because Mr Snowden offered himself as a convenient antagonist to needle the United States.

The White House, of course, has not escaped criticism from some quarters at home. Some are asking why, when the U.S. and the Soviet Union managed to hold summits even during the depths of the Cold War – when the divide separating the rival superpowers was even greater – why President Obama, who has regularly stood by his faith and doctrine in resetting relations with Russia, could not have gone through with the September Summit?

Any historical comparison, though, is false; the Cold War ended almost 22-years ago, and America has always been perceived as the silent victor. But as Mr Obama has rightly pointed out, the Kremlin acts as if it continues, almost reflexively, to take the opposite point of view to Washington on every conceivable problem of the moment. Putin’s nationalistic approach to a domestic audience may play well at home with some, but one may wonder whether the Russian President has even noticed how much the world has changed since the demise of the Soviet Union in December 1991 when the red flag with the hammer and sickle was hauled down for the last time from the Kremlin towers.

No one should doubt that the global balance of power is turning against the West, but Russia cannot be classified as being among the world’s rising powers. For one, the country’s population is in remorseless decline. Poor health, alcoholism and emigration are steadily reducing the number of Russian citizens. The UN has forecast that by 2050 the country will have lost some 36 million people, reducing its overall population to 107 million – Uganda, a country whose territory is less than 2 per cent the size of Russia, has a population not much above 103 million.

Compare and contrast America, with a populace of more than 300 million people – or even Britain, which now has the fastest growing population in Europe. The UK adds about 400,000 people every year, which is close to the annual rate at which Russians are dying off. While some Britons remain uneasy over the scale of immigration on these islands, it is true that fewer people make a weaker economy.

And another reason for Russia’s long-term decline is due to its actual economic health. Today, the American economy remains eight times bigger than Russia’s. Remarkably, too, is that Russia’s gross domestic product is still 30 per cent smaller than Britain’s. Its economic strength has been artificially inflated by high oil prices and the vast energy reserves it has at its disposal. Despite that, Russia’s customers are increasingly turning to shale gas from fracking, and future oil prices will become an uncertain indicator for economic health.

Whilst it is true that Russia can act as an obstructionist on a range of international issues (Syria being one such example) one should seek to understand whether Mr Putin is deliberately irritating the U.S. rather than being a competitive rival to the West.

Today, military might and the size of a country’s nuclear arsenal count far less than its economic prowess, its entrepreneurialism, competitiveness and how central it is to the global trading system. With neither the EU nor China having the desire to send fleets and armies to the opposite ends of the earth, the United States remains the autonomnous military superpower having achieved that position largely by default. Despite Mr Putin’s bluster, Russia no longer has the capacity it once had in challenging America as a superpower.

Economically, Russia is a mid-sized power, with a GDP that is barely a 10th of that of the US. Russia is often quoted for its corruption, its scant respect for the rule of law and its continued dependence on raw materials, particularly oil and gas.

Had September’s summit gone ahead, Mr Obama would have been on a hiding to nothing as Vladimir Putin’s obstructionist style would have seen to that. Such summits are not spontaneous, one-off occasions, but are carefully choreographed and prepared; usually communiqués are worked out well in advance. Presently, however, apart from the evident dislike between the two men, the differences appear unbridgeable – on Syria’s continuing bloody civil war, missile defence and Mr Putin’s internal repression, to name but a few of the issues. Moscow’s granting of asylum status to Edward Snowden would have been the last straw. Had Mr Obama attended the summit in Moscow and returned empty-handed, as was all but certain, he would have been pilloried at home by Republicans as being weak and over-trusting.

With bilateral relations as low as they are, it isn’t inconceivable to say they will remain that way so long as Mr Putin is on the world stage.

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