Tag Archives: Heart disease

Health, Medical, Research, Science

Injection of antibodies could reduce risk of heart attacks and strokes

MEDICAL RESEARCH

THOUSANDS of lives could be saved every year after scientists discovered a group of antibodies that dramatically reduce the risk of heart attacks and strokes – and revealed plans to develop an injection of the substance for those most at risk.

The researchers say their discovery could lead to the development of a test to determine a person’s risk of heart disease within three years and an antibody injection to protect them in as little as five years.

A lead researcher at Imperial College London, said: “If this line of research is successful it would mean a revolution in tackling the biggest killer in the world.”

Everybody has at least some of these antibodies, but levels vary widely between people and that plays a crucial role in determining how likely they are to suffer life-threatening heart problems.

The effect of the antibodies is so profound that people with high levels of them are 70 per cent less likely to develop heart disease than people with low levels of them.

High levels of the antibodies show their hosts have less of the dangerous plaques in their arteries that cause most heart attacks and strokes.

The discovery has the potential to save numerous lives, leading heart specialists have said.

More than 100,000 people in the UK die each year from a cardiac arrest or stroke that has been caused by plaque on the inside of an artery. By discovering which patients have plaques that are more likely to rupture and why, thousands of lives a year could be saved.

The development of new drugs might be used to tweak the immune system to prevent people from having a heart attack or stroke.

The British Heart Foundation is known to have funded much of the research and has given Dr Khamis – a consultant cardiologist at Hammersmith Hospital – £1million to develop his work further. He is working on a blood test to identify people at high risk of heart disease by measuring levels of the antibody. He hopes this will be available on the NHS in the next three to four years.

Those people identified as being most at risk can then make lifestyle changes to reduce the threat.

Even more significant, Dr Khamis is also developing an antibody injection that could be given to patients at high risk, which he hopes would be available in the next five to ten years.

However, he cautions more research is needed on both the test and the treatment to confirm their effectiveness before they could become available.

Scientists do not yet fully know why some people have higher levels of the antibodies.

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Government, Health, Medical, Research, Science, Society

Health risk for women in their 30s who do not exercise…

HEART RISK

A major study has found that a lack of exercise puts younger women at far greater risk of heart attacks than smoking or being obese.

Researchers found inactive women in their 30s are almost 50 per cent more likely to develop heart disease in their lifetime than those who are fit.

The team has now called on governments to launch public health campaigns on the importance of exercise, arguing it would have a far greater impact on reducing heart disease deaths than drives to discourage smoking or promote healthy eating.

The scientists looked at the records of 32,541 women aged 22 to 90, including details about lifestyle and whether they had heart disease. Armed with this data, they used a mathematical formula to work out their risk of heart disease during their lifetime based on whether they were inactive, were smokers, had hypertension (high blood pressure) or were obese.

A lack of exercise was found to pose the greatest risk to women across all age groups.

Those in their early 30s who were classed as inactive were nearly 50 per cent more likely to suffer from the condition in their lifetime than active women.

The risk decreased slightly with age. Inactive women in their late 40s were 38 per cent more at risk, falling to 28 per cent in the late 50s.

By comparison, the risk was 40 per cent for women smokers in their 30s and 30 per cent for the obese. Although obesity and being unfit are closely linked, the researchers from the University of Queensland pointed out that many slim women are inactive.

The latest UK figures show a quarter of women are classified as inactive, while just over half do the recommended two and a half hours of physical activity a week.

Heart disease, which includes heart attacks and strokes, is by far the biggest killer in Britain, claiming 82,000 lives a year.

Experts have previously claimed that exercising can halve the risk of getting the condition because it lowers the blood pressure, reduces cholesterol which blocks arteries, and improves circulation.

Professor Wendy Brown, one of the team’s lead researchers, described inactivity as the ‘Cinderella risk factor’ for heart disease. She said: ‘Our data suggests that national programmes for the promotion and maintenance of physical activity across the adult lifespan, but especially in young adulthood, deserve to be a much higher public health priority for women than they are now.’

The study’s findings, first published in the British Journal of Sports Medicine, concluded: ‘Continuing efforts to reduce smoking rates in young adult women are warranted… however, from about age 30, the population attributable risk for inactivity outweighs that of the other leading risk factors, including high Body Mass Index, which is currently receiving much more attention.’

A spokesperson for the British Heart Foundation, said: ‘We already know physical inactivity is a major risk factor for heart disease. Interestingly, this study shows its dominant influence on heart disease amongst women, and suggests a greater need to promote regular physical activity… It is important to remember that heart disease is linked to other factors such as smoking, obesity, high blood pressure and high cholesterol.’

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Health, Medical, Research, Science

Indigestion drugs linked to risk of heart attacks and strokes…

PROTON PUMP INHIBITORS (PPIs)

Common indigestion drugs used by millions of Britons could increase the risk of heart attacks and strokes, according to research.

Scientists said the drugs, called proton pump inhibitors, or PPIs, can trigger a dangerous rise in chemicals in the body linked with heart disease.

Patients with existing heart problems, such as angina, are at most risk, but healthy adults with no history of such complaints could also be affected, the researchers said.

The number of prescriptions for PPIs such as lansoprazole and omeprazole – sold over the counter as Zanprol – has doubled in recent years to more than eight million a year, costing the NHS around £400 million a year. The exact number of patients on the drugs is not known because some buy them over the counter (OTC) at high street chemists.

PPIs work by blocking the action of cells called proton pumps, which produce stomach acid. Although very effective, they should only be used for a maximum of two months and preferably for between two and four weeks.

But many patients quickly find they cannot live without them and ask for repeat prescriptions from their GP or buy them at the chemist. Previous studies identified a potential link between the drugs and heart problems, although scientists conceded there was no obvious explanation for the connection.

Now experts at the Methodist Hospital Research Institute in Houston, Texas, believe they have uncovered the reason why.

After studying samples of human heart tissue, as well as carrying out experiments on mice, they found that PPIs triggered an increase in a chemical called asymmetric dimethylarginine, or ADMA, produced as the body’s cells make proteins.

It can hinder blood flow by blocking the release of nitric oxide, a gas which helps arteries to stay flexible and healthy. The latest findings, published in the journal Circulation, show PPI medicines increase ADMA levels by about 25 per cent and reduce the ability of blood vessel walls to relax by more than 30 per cent.

In a report on their findings, the researchers said that several studies have raised concern that the use of PPIs in patients with acute coronary syndrome (heart disease) may increase their risk of major adverse events.

Dr John Cooke, who heads the research group, says that whilst a plausible biological explanation has now been found to explain this, also added that the ‘surprising effect still needs further investigation’.

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