Health, Medical, Science

Menopause misery. HRT isn’t the only answer

HEALTH

DR MAX PEMBERTON, an NHS psychiatrist and medical doctor, wrote recently on the significant shift in many doctors’ attitude towards Hormone Replacement Therapy (HRT). For far too many years, peri- and post-menopausal women have to had to fight hard for their right to access this medication.

An increasing number of doctors are now open to the idea that prescribing HRT can have real benefits for their patients – and, undoubtedly, this has made a life-changing difference for many women. Even though some 13million women in the UK are going through the menopause, it is estimated that one in four have to visit their GP at least three times before getting appropriate treatment.

Last year, official draft guidelines were issued to GPs which said alternative treatments should be considered. These included talking therapies “alongside or as an alternative to” HRT to help reduce menopause symptoms such as insomnia, low mood, and hot flushes. These guidelines have now been revised with health officials backtracking after accusations of “medical misogyny” – the implication being that menopausal symptoms were “all in the mind”. The guidance issued by NICE now advises that HRT should be offered as the first line of treatment. Some may believe this a positive development, but Dr Pemberton is unsure.

The medic is known to be a keen fan of HRT and he has seen many patients’ lives transformed by it. But he goes on to say that HRT isn’t suitable for everyone and that talking therapies can help those women presenting with symptoms that have a psychological component.

Dr Pemberton says that many women talk about no longer feeling like themselves, a disconcerting sense of something having changed, a vague undercurrent of unease, despair, and discombobulation. Trying to address what causes this turmoil is far more complicated than simply a blip in hormone levels. And neither can it be explained away by a woman’s dissatisfaction with life and her sense of loss and malaise as a chemical reaction.

That’s not to say that hormones don’t play an important part. Medical professionals know that fluctuations in hormones can be responsible for low and poor mood.

Over the years, Dr Pemberton has seen far too many women struggling to cope and for whom HRT has been hugely beneficial – helping them, for instance, to manage anxiety caused by the menopause.

But the medic also believes there are other factors that contribute to a woman’s sense of losing herself. He points out that low mood and anxiety are a result of complex social and psychological factors, rather than simple biology.

Changes to the body, disrupted sleep, hot flushes, and so on, he says, can make any woman feel out of control and depressed.

Dr Pemberton documents and records other issues he’s heard women talk about – for example, erratic mood swings and out-of-character behaviour. There are stories of women having affairs, quitting their jobs, or leaving their husbands around the menopause.

While some would seek to blame this all on fluctuations in hormone levels, the evidence for this isn’t that compelling.

The clinician says it’s not at all clear that drops in oestrogen and progesterone, the female sex hormones that start to decline in menopause, are entirely responsible.

Rather, the medic believes that the menopause acts like a ticking clock. It suddenly makes women open their eyes and review their lives. Much of the trauma and emotional turmoil that besets many women as they navigate menopause isn’t the consequence of fluctuating hormones but of a re-evaluation of their life’ situation. For many, their sense of self and identity is closely bound up with their roles within their family, particularly those who are mothers, who may feel bereft at the prospect of an empty nest.

It is also a cruel aspect of the inequality between the sexes that women have to contend with a society that’s more judgmental about how woman age than men. For a lot of women in their 50s and 60s, they have given the best years of their lives to other people and their careers, and now they’re not sure why. A vast number of menopausal women now feel invisible.

Dr Pemberton has had many menopausal and post-menopausal women attending his clinics and hearing the sad story that they no longer feel like a woman.

It is here, he says, that these people would surely benefit from having the time and space to explore and discuss their feelings and situation. That’s where talking therapies can play a vital role for many who have become desperately unhappy.

In the opinion of Dr Max Pemberton, the answer to many complex problems precipitated by the menopause aren’t always going to be found in HRT pills, patches, and gels.

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Health, Medical, Research, Science

HRT and the menopause: benefits now thought to outweigh risks…

After more than a decade of controversy, medical experts say that Hormone Replacement Therapy (HRT) for women in their 50s is safe in combating the menopause.

Taking medication to reduce the symptoms of the menopause is now deemed safe and the benefits for women on HRT are now thought to far outweigh the potential risks. Freshly released guidance from the British Menopause Society (BMS) has sought to reassure patients.

Medical experts say hundreds of thousands of women have suffered unnecessarily as a result of the decade-long controversy over the effects of HRT.

They say that General Practitioners (GPs) should prescribe the treatment to any woman who has unpleasant menopausal symptoms, such as hot flushes and mood changes. HRT is also known to provide bone protection in later life.

However, the debate over HRT use is likely to rage on as The Royal College of Obstetricians and Gynaecologists continues to advise HRT prescription only for women with serious menopausal symptoms ‘for the shortest time possible’.

After a period of five years doctors are not expected to continue prescribing HRT medication without discussing potential risks with their patients.

Uptake of HRT halved after two studies linked it to an increased risk of heart disease and breast cancer. An estimated one million women in the UK stopped having the treatment.

But the emerging consensus now is that the benefits of HRT outweighed the risks for most women, and that GPs should consider the updated BMS advice when treating the condition.

Consultant Endocrinologist Dr Helen Buckler, from the University of Manchester, speaking at the Cheltenham Science Festival, said the two studies linking HRT to breast cancer and heart disease were ‘scientifically unreliable’.

She said:

… The new advice is HRT should be used for a slightly wider age, if need be. If a woman has symptoms affecting the quality of her personal or professional life, then the benefits outweigh the risk.

The scare of taking HRT began in 2002, when the US Women’s Health Initiative study was halted some three years early because researchers claimed women using HRT were at a higher risk of breast cancer, heart disease and strokes. Yet, this contradicted previous (and later) research which suggested its use guarded against heart problems.

HRT is normally prescribed to menopausal women in their 50s, but according to the WHI study it was also given to women in their 60s and 70s who had gone through the menopause more than a decade earlier.

Shortly afterwards the UK Million Women Study, part funded by Cancer Research, a charity, said HRT doubled breast cancer risk, but a review in 2012 said it was ‘unreliable and defective’.

The advice from Cancer Research remains that there is still convincing evidence that women who take HRT have an increased risk of breast cancer. Dr Buckler, though, said the organisation was ‘out of step’ and its approach had tended to ‘put women off’ taking the treatment.

Some younger doctors have never prescribed HRT because they assume the risks outweigh the benefits.

Cancer Research UK said there was ‘convincing evidence’ that women who take HRT have an increased risk of breast cancer, but says that risk returns to normal around five years after the medication is stopped being used.

The BMS guidance is also opposed to the ‘arbitrary’ five year limit on treatment, and says it should be continued if symptoms persist.

The BMS, a registered charity and medical foundation, receives no government funding. Its medical advisory council comprises leading international experts in post reproductive health management, who regularly draw up guidelines for health professionals.

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