Britain, Health, Medical, Research, Science

New treatment options emerge for Parkinson’s disease…

RESEARCH LINKS THE DISEASE WITH A GENETIC DEFECT

… Scientists believe they are closer to treating debilitating Parkinson’s disease.

Parkinson’s disease is caused by a genetic defect that produces poor ‘housekeeping cells’, but scientists now believe they are closer to treating the debilitating condition.

Scientists have linked the disease to a genetic malfunction that prevents cells from clearing out defective mitochondria, metabolic generators within the body’s cells that supply energy. Dysfunctional mitochondria are potentially very harmful.

Normally, cells dispose of them through a ‘hazardous waste’ management system known as mitophagy. This causes bean-like bodies to be digested and broken down.

But researchers have now discovered and identified a biological pathway that allows mutations in a gene – called FBxo7 – to interfere with mitophagy.

For Parkinson’s sufferers, this leads to a build-up of defective mitochondria that may result in the death of brain cells.

The study, first published in the journal Nature Neuroscience, indicates that mitophagy might be the key to new treatment options for the disease.

Dr Helene Plun-Favreau is one of the researchers based at the Institute of Neurology at the University of London. She said:

… These findings suggest that treatment strategies that target mitophagy might be developed to benefit patients with Parkinson’s disease in the future.

… What makes the study so robust is the confirmation of defective mitophagy in a number of different Parkinson’s models, including cells of patients who carry a mutation in the Fbxo7 gene.

Co-author of the study, Dr Heike Laman, from Cambridge University, said:

… This research focuses the attention of the Parkinson’s disease community on the importance of the proper maintenance of mitochondria for the health of neurons.

… We are really only at the very beginning of this work, but perhaps we can use this information to enable earlier diagnosis for Parkinson’s disease patients or design therapies aimed at supporting mitochondrial health.

Professor Hugh Perry, chair of the neurosciences and mental health board at the Medical Research Council which part-funded the study, said the work raised ‘interesting questions’ about brain cell death related to Parkinson’s. He said:

… The more we understand about the basic molecular events which contribute to the onset and progression of Parkinson’s disease, the better placed we will be to develop treatments to stop it in its tracks.

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Banking, Britain, Business, Economic, Finance, Financial Markets, Government, Society

Bank of England Governor turns fire on bankers…

BANK REFORM

The bank governor is determined to prevent a Japan-style economic crisis in the UK.

The new Bank of England governor, Mark Carney, has launched a stinging attack on ‘socially useless’ bankers and has called for a ‘change of culture’ in the industry.

The former Golden-Sachs executive, who succeeded Lord King as governor of the Bank of England last month, hit out at self-obsessed bankers who are, he says, detached from reality.

The Canadian has also defended the decision to peg interest rates to unemployment – a move that looks set to see rates remaining at 0.5 per cent for at least another three years.

Mr Carney expressed ‘tremendous sympathy’ for savers who have ‘done the right thing’ but insisted drastic action was needed to ‘secure the recovery’ and prevent a Japanese-style economic crisis in Britain.

This followed his announcement last week that the Monetary Policy Committee (MPC) will not raise rates from o.5 per cent until unemployment falls to 7 per cent or lower. Unemployment is currently running at 7.8 per cent and is not expected to reach the new threshold until the end of 2016.

Turning his fire on the banking industry, Mr Carney said:

… There has to be a change in the culture of these institutions.

He said that ‘finance can absolutely play a socially useful and economically useful function’, but added it must focus on ‘the real economy’. The Bank governor said banking is ‘socially useless’ when it becomes ‘disconnected’ from the economy and society and ‘only talks to itself’.

Mr Carney, who is also chairman of global banking watchdog the Financial Stability Board, added:

… A lot of what we are doing internationally is to strip out this type of behaviour.

The Canadian said the decision to peg interest rates to unemployment – a tactic known as ‘forward guidance’ by central banks – would boost the economy by ‘more than half a percentage point of GDP’ over the next three years.

Amid a fierce backlash from savers he insisted low rates were required to ensure the economy finally recovers from the biggest boom and bust in history.

‘The best way to get interest rates back to normal levels is to have a strong economy,’ he said. ‘We’re in the very early stages of a recovery from the weakest period on record.’

He said Japan made two mistakes after its recession in the early 1990s – failing to fix the banking system and pulling back from measures to stimulate the economy too quickly.

… As a consequence, almost a quarter of a century later, interest rates are still at rock bottom levels in Japan… We don’t want to make those mistakes here in the UK.

COMMENT

Mark Carney’s predecessor, Lord King, started a hard line on the need for banks to reform their cultural practices, by being useful contributors to society and by insisting that they strengthen their balance sheets so they no longer expose the taxpayer to excessive risk.

In some recesses of the banking sector, the appetite for running their operations on wafer-thin levels of capital remained undiminished by the worst financial crisis the world has ever seen.

Some in the City of London had hoped that Mr Carney would administer a snub to King by letting off bankers more lightly.

Given the governor’s role as chairman of the Financial Stability Board, and his personal championing of higher leverage ratios whilst at the Bank of Canada, that always seemed improbable – and so, thankfully, it has proved.

The Bank of England governor, Mark Carney, has defended the decision to peg interest rates to unemployment – a move that looks set to see rates remaining at 0.5 per cent for at least another three years.

The Bank of England governor, Mark Carney, has defended the decision to peg interest rates to unemployment – a move that looks set to see rates remaining at 0.5 per cent for at least another three years.

In his first public pronouncement on the subject Mr Carney made it crystal clear that he, no less than King, wants the banks to start serving the real economy instead of just themselves. He made a point of praising King’s work in improving bank balance sheets and of name-checking Andrew Bailey, who heads the Prudential Regulation Authority, the body that controversially forced Barclays and Nationwide to raise more capital.

The governor’s backing for the moves to make these two financial institutions formulate credible plans to increase their base capitals can longer be in question.

The great myth put about by the banking lobby is that higher levels of capital automatically constrain their ability to lend to households and firms and so hold back growth at a time when the economy is weak.

Whilst this seems to be a notion that has been swallowed wholesale by some in the Treasury and the Department of Business, it is not true.

Banks can improve their capital position by retaining earnings, scaling down bonuses and cutting back on other types of less socially useful business.

The new rules will, over the long-term, increase lending to the real economy, not harm it, and will give us safer and more secure banks, which can only be good for stability and growth.

Undoubtedly, there are plenty of questions over Mr Carney’s big idea of forward guidance, from the impact it will have on savers and on pensions, the risks to inflation and the distinct absence of a clear message due to the get-out clauses.

But on bank reform and conditions for capital holdings, Mr Carney should be applauded.

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Arts, Environment, Nature, Photography

MD Photography: Eurasian Eagle-Owl…

Eurasian eagle-owl, south-west Scotland. Photograph: © Mark Dowe 2013: all rights reserved

ABOUT THE EURASIAN EAGLE-OWL

Eagle Owls occupy a variety of habitats, from coniferous forests to warm deserts. Rocky landscapes are often favoured. Adequate food supply and nesting sites seem to be the most important prerequisites.

Usually most active at dawn and dusk, the Eurasian eagle-owl has a powerful, fast flight, which is somewhat reminiscent of that of a buzzard. Hunting occurs from an open perch or in flight, and the owl may also search rock crevices for roosting birds, take both adult and young birds from nests, or even plunge into water to capture fish. The diet mainly consists of mammals, up to the size of adult hares or even young deer, as well as birds up to the size of herons and buzzards, and occasionally amphibians, reptiles, fish and insects.

The Eurasian eagle-owl usually begins breeding from late winter. The nest might be located on a sheltered cliff ledge, in a cave or crevice, in the old nest of another species (such as storks or large birds of prey), or occasionally in a tree hole or on the ground. The species has always been considered to be monogamous, but some cases of bigamy have been recorded recently. A breeding pair may use the same nest site over several years. Between one and five eggs are laid, and are incubated by the female for 34 to 36 days, during which time the male brings food to the nest. The young owls first leave the nest at around five weeks, but cannot fly until about seven weeks old, and remain dependent on the adults for a further three to four months, not generally starting to disperse until approximately 170 days old. The Eurasian eagle-owl reaches sexually maturity at 1 year, and may live up to 21 years or more in the wild, or to an impressive 60 years in captivity.

The Eurasian eagle-owl has one of the largest ranges of any eagle-owl, being found across much of Europe, through the Middle East, Russia and Asia, and as far east as China, Korea and Japan. Although generally absent from Britain and Ireland, small numbers are now beginning to breed in Britain.

This owl usually inhabits natural rocky areas with cliffs and ravines, as well as quarries and buildings, patches of woodland or scattered trees. It also occurs in open forest, taiga, wooded steppe, semi-desert, and farmland with suitable rocky areas, and can be found at elevations of up to about 2,000 metres in Europe and 4,500 metres in Central Asia and the Himalayas. More recently, this species has started to colonise urban habitats and is now breeding in several towns in Europe.

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