Arts, Environment, Science

A Life of Useful Purpose?

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Health, Medical, Research

New Alzheimer’s drug offers hope to sufferers

DEMENTIA/ALZHEIMER’S DISEASE

THE first new pharmaceutical drug for Alzheimer’s in almost two decades has won approval in the United States – raising hopes that the drug could soon be used in the UK.

Aducanumab targets the cause of the disease rather than its symptoms.

Medical and health charities have welcomed the announcement, describing its approval as a “major milestone” for the millions of people living with dementia. But scientists are divided because of the uncertainty over trial results.

The US Food and Drug Administration said there was “substantial evidence that aducanumab reduces amyloid beta plaques”. Amyloid is a protein that forms clumps in the brain that can damage cells and trigger dementia. Aducanumab works by sticking to these clumps and removing them.

However, late-stage international trials of the treatment in 2019, involving about 3,000 patients, were halted when analysis showed the drug was no better at slowing the deterioration of memory than a placebo. Following further analysis, manufacturer Biogen said the drug did work and significantly slowed cognitive decline if given in higher doses.

Biogen have not released the cost of the treatment, but analysts estimate it could cost up to £35,000 a year. Tens of thousands of Britons with a mild form of the disease could be suitable for the drug if it were to be approved here.

Professor Bart De Strooper, director the UK Dementia Research Institute, said: “With no effective therapies currently available to modify the progression of this devastating condition, this is a major milestone for the millions of people living with Alzheimer’s. However, I fear the controversy and uncertainty surrounding the trials will limit the impact of this new treatment for the disease.”

A spokesperson for the research department at the Alzheimer’s Society, said: “It’s promising to see that aducanumab has been approved for use in people with early-stage Alzheimer’s disease – the first drug to be approved in nearly 20 years by the US regulatory authorities.

“We await the opinion of the European Medicines Agency and the outcome of any application made to the UK regulatory authorities, to give clarity to people with early Alzheimer’s disease in the UK. Whatever the outcome of their decision, this is just the beginning of the road to new treatments for Alzheimer’s disease.”

Another health charity, Alzheimer’s Research UK, said it had written to UK Health Secretary Matt Hancock asking the Government to prioritise the fast-track approval process for the drug in the UK.

Its chief executive, Hilary Evans, said: “People with dementia and their families have been waiting far too long for life-changing new treatments.”

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Health, Psychology, Research, Science

Positive Psychology: Barriers to well-being

BARRIERS TO HAPPINESS AND WELLBEING

ON May 9, 2021, an entry was made on this site concerning ‘happiness’ and the factors that can affect it. You might like to refer back to it.

The article looked at various tried and tested pathways to happiness, such as the five components of Martin Seligman’s well-being theory: positive emotion, engagement, relationships, meaning and accomplishment.

But is happiness that easy to attain? Surely if it were that simple, we’d all feel pretty upbeat all the time. In practice, there are several psychological obstacles which stand in the way of us achieving long-lasting happiness and contentment, and it’s worth knowing what these are so that we can try to overcome them. This entry will explore the five main barriers to well-being.

Barrier 1: the negativity bias

The negativity bias refers to our tendency to pay more attention and give more weight to negative emotions, experiences, and information than to positive ones. This means that you’re more likely to remember (and take seriously) an insult, a criticism or a piece of negative information or feedback than a compliment or a piece of positive information or feedback. From an evolutionary perspective this makes perfect sense since we would not have survived as a species had we not been finely attuned to notice the actual dangers and possible risks all around us. But now that there are far fewer threats in our lives (whatever the media says), this in-built negativity bias can get in the way of our well-being.

Studies also show that positive and negative information of the same importance do not hold equal weight in our minds. If we are given two pieces of equally important information about a stranger, one positive and one negative, they don’t balance each other out – we’re more likely to form a negative view of the person than a neutral one. Similarly, if we have had a good experience and bad experience close together, we will feel worse than neutral, even if the two experiences are of a similar importance. The evidence suggests that positive and negative emotions are not equal, or, in other words, negative emotions reduce our level of well-being more than positive emotions increase it. This helps to explain why it is important to experience positive emotions frequently.

Psychologist Roy Baumeister and colleagues summed up the impact of the negativity bias in five words: “bad is stronger than good.”

Barrier 2: duration neglect

It seems logical that the duration of an experience should influence how we feel about it and how we remember it. A two-week holiday in the sunshine on a glorious tropical island should feel twice as good as exactly the same holiday in the same location lasting for one week. Likewise, undergoing a negative experience such as a 20-minute dental procedure should feel twice as bad as a 10-minute procedure, assuming we feel the same intensity of discomfort throughout both.

So, it may surprise you to discover that when we evaluate our positive and negative experiences, their duration hardly matters at all, which psychologists call duration neglect. Factors which are considered more important are, 1) the intensity of the peak positive or negative emotion, and 2) how the experience ends. So, if we undergo a painful medical procedure which lasts 20 minutes, as long as the pain we experience at the end is less severe than our worst experience of pain during the procedure, we’ll actually remember it more favourably than the same procedure in which the worst pain is the same, but which is only half as long.

In practice this means that if we want to increase our well-being, and that of other people, we should deliberately look for ways to end experiences on a high note. This might just be a simple thing such as when leaving work at the end of the week, you wish colleagues a good weekend. Or, if you have to do something like a presentation, make sure you end it on a high, and practise a positive ending until it comes naturally.

Barrier 3: social comparison

We use the expression “keeping up with the Joneses” to refer to the comparison we make with others – such as our neighbours – to determine how well we’re doing in life. If we buy things to keep up with the Joneses, it means we’re not doing it out of necessity, but as a way of maintaining social status. So, even if our standard of living is acceptable from an absolute perspective, if it’s lower than our peer group our well-being will be diminished.

If we see people around us (family, friends and colleagues) buying more or better things than us, it makes us feel worse about our lives. Thus, how much we earn or buy in comparison to others has an impact on our well-being. That others may be up to their eyeballs in debt to acquire all these new goods barely registers. If they’ve got it, we feel that we’ve got to have it too. This is all made much worse by celebrity lifestyles which are splashed across the internet, TV and magazines, plus the advertising and brand endorsements which accompany them. The problem occurs because, unbeknownst to many of us caught up in the endless must-have-more cycle, buying more things in an effort to keep up with the Joneses will never make us feel happier. The reason? It’s what positive psychologists have dubbed the hedonic treadmill.

Barrier 4: the hedonic treadmill

The bad news – Think of the last big purchase you made, the last time you were promoted or given a pay rise. Remember how excited and happy it made you feel? Now think how long you stayed excited and happy. A few days? A week? In all likelihood, it wasn’t very long. We adapt, we get used to things, whether it’s the things we buy or other positive events and experiences in our lives. When that happens, we start taking them for granted, quickly reverting to our usual happiness baseline (also called the “set-point”). This is what happens when “the novelty wears off”.

In reality, the hedonic treadmill means that there’s little point in expecting shopping and material goods to raise your well-being permanently. They may give you a little boost of positive emotion in the short term, but the bad news is that it won’t last, and you’ll soon feel exactly as you did before. Worse still, you may feel driven to buy something else in order to make yourself feel better again. And so, it goes on. And on.

Sadly, this adaptation principle also applies to other pleasant experiences or circumstances, such as getting married. In research, the average person does not experience a lasting boost to their satisfaction after marriage. Instead, they experience a short-term increase in happiness, followed by a return to their baseline level beyond the early years.

The potential good news – On the other hand, this process of psychological adaptation also applies to unfavourable circumstances, which means that if bad things happen, we will feel worse in the short or medium term before eventually coming back up to our baseline or set-point level of happiness. However, research suggests that we adapt much more quickly to positive events and experiences than we do to negative ones.

There are two take-away messages from the hedonic treadmill story. The first is that you should expect the boost you get from positive experiences like shopping to wear off pretty quickly. The second is that over the longer term it’s worthwhile investigating other, more sustainable routes to well-being. And if you’re married or contemplating getting married, remember that it’s not a guaranteed pathway to permanent happiness – you’ll have to continually work at your relationship if you wish happiness to be your priority.

Barrier 5: lack of self-control

The fifth barrier to well-being is lack of self-control. Self-control (often called self-regulation) refers to our ability to control our impulses and channel our effort in a way that will allow us to reach particular goals. You’re not alone if you think you have low self-control – one study of the 24 character strengths of over 83,000 adults found that self-regulation scored lowest. But self-control is important; according to psychologists Mark Muraven and Roy Baumeister, lack of self-regulation is at the heart of many of the social and personal problems that we suffer in the modern, developed world.

Contrary to the popular view that happiness results from giving in to our natural desires, psychology studies show that higher well-being is actually linked to higher self-control. So, it makes perfect sense to find ways to increase your self-control. Luckily, self-control is bit like a muscle, the more you practise it, the stronger it gets. Developing self-control in one life domain can help to strengthen your self-control in other areas.

THINGS TO REMEMBER

. We naturally give negative emotions, experiences, and information more attention than positive ones.

. Negative and positive experiences of roughly the same importance do not cancel each other out – generally the negative experience will affect you more.

. Shakespeare was right – it’s true that all’s well that ends well! Try to ensure that negative events and experiences end on a high note.

. Comparing yourself upwards is likely to reduce your well-being. Comparing yourself downwards is likely to increase it.

. The novelty almost always wears off.

. Self-control is like a muscle: it improves with practice.

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