Health, Medical, Research, Science

Injection of antibodies could reduce risk of heart attacks and strokes

MEDICAL RESEARCH

THOUSANDS of lives could be saved every year after scientists discovered a group of antibodies that dramatically reduce the risk of heart attacks and strokes – and revealed plans to develop an injection of the substance for those most at risk.

The researchers say their discovery could lead to the development of a test to determine a person’s risk of heart disease within three years and an antibody injection to protect them in as little as five years.

A lead researcher at Imperial College London, said: “If this line of research is successful it would mean a revolution in tackling the biggest killer in the world.”

Everybody has at least some of these antibodies, but levels vary widely between people and that plays a crucial role in determining how likely they are to suffer life-threatening heart problems.

The effect of the antibodies is so profound that people with high levels of them are 70 per cent less likely to develop heart disease than people with low levels of them.

High levels of the antibodies show their hosts have less of the dangerous plaques in their arteries that cause most heart attacks and strokes.

The discovery has the potential to save numerous lives, leading heart specialists have said.

More than 100,000 people in the UK die each year from a cardiac arrest or stroke that has been caused by plaque on the inside of an artery. By discovering which patients have plaques that are more likely to rupture and why, thousands of lives a year could be saved.

The development of new drugs might be used to tweak the immune system to prevent people from having a heart attack or stroke.

The British Heart Foundation is known to have funded much of the research and has given Dr Khamis – a consultant cardiologist at Hammersmith Hospital – £1million to develop his work further. He is working on a blood test to identify people at high risk of heart disease by measuring levels of the antibody. He hopes this will be available on the NHS in the next three to four years.

Those people identified as being most at risk can then make lifestyle changes to reduce the threat.

Even more significant, Dr Khamis is also developing an antibody injection that could be given to patients at high risk, which he hopes would be available in the next five to ten years.

However, he cautions more research is needed on both the test and the treatment to confirm their effectiveness before they could become available.

Scientists do not yet fully know why some people have higher levels of the antibodies.

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Architecture, Arts, Culture, Scotland

The V&A Museum of Design

SCOTLAND

DUNDEE’S equivalent of the Pompidou in Paris or Bilbao’s Guggenheim is now on full view. The V&A, designed by Kengo Kuma, is simply staggering.

With its instantly recognisable outline – part sea cliff, part galleon – the £80.4million V&A Museum of Design may soon find itself revered as a global design icon.

Certainly, few who have seen Scotland’s first dedicated design museum are likely to be left unmoved by its dizzyingly ambitious zigzag slabs of rough concrete, described variously as a crash-landed Egyptian pyramid, the ribbed carcass of a beached whale and the ragged remains of a mighty shipwreck. Art in its full splendour and glory.

On display: The £80million museum’s collection is expected to attract 500,000 visitors in its first year.

Following its official opening, the “V&Tay”, as it is ostensibly and affectionately known to its London colleagues, is expected to attract some 500,000 visitors from around the world in its first year alone, generating tens of millions of pounds for the local economy.

Critics may welcome a time when this controversial project starts to pay its way, having been blown off course by years of construction delays and escalating costs before finally anchoring itself at the heart of the city’s £1billion waterfront regeneration.

Since its conception, the original £45million budget has almost doubled and its Japanese architect and designer had been forced to tow his initial plan for a water-bound structure back to dry land.

On the V&A’s opening, however, a preview which was attended by dozens of the world’s media, Mr Kuma pronounced himself satisfied that his vision to create a “living room for the city” had been realised.

The attraction’s galleries showcase 300 objects, including Charles Rennie Mackintosh’s Oak Room and the painstakingly reconstructed interior of Miss Cranston’s Ingram Street tearoom which has not been seen for 50 years.

Mr Kuma said: “It is fitting that the restored Oak Room by Charles Rennie Mackintosh is at the heart of this building as I have greatly admired his designs since I was a student.

“In the Oak Room, people will feel his sensibility and respect for nature, and hopefully connect it with our design for V&A Dundee. I hope the museum can change the city and become its centre of gravity.”

He said the magisterial light-filled atrium with its sweeping staircase and waves of oak panel boards was a nod to Mackintosh, who was deeply influenced by oriental art and design.

Mr Kuma said: “When I saw [Mackintosh’s] buildings as a student I was very surprised at how Japanese they were. Japanese quality, [and] Japanese sensitivity exist in his designs.”

Everywhere in the museum, glimpses of the Tay can be caught through small windows, while the hall and stairs glint with fossilised coral set into limestone flooring.

Complementing his daring design are the – often quirky – exhibits of the Scottish Design Galleries, from the so-called Valkyrie tiara, created by Cartier using more than 2,500 diamonds for Mary Crewe-Milnes, Duchess of Roxburghe, in 1935, to cutting-edge environmental material crafted from the fibres of stinging nettles by Dundee-based firm Halley Stevensons for Glasgow backpack-maker Trakke.

There is also some hand-coloured Beano artwork for a Dennis the Menace cartoon strip from 1960.

Also in the collection is the largest remaining fragment of the Titanic – part of a door from the first-class lounge of the liner – and a costume worn by Natalie Portman’s character, Padmé Amidala, in Star Wars: Attack of the Clones, which was created by Trisha Biggar, the Glasgow designer.

A full-sized clay model Jaguar car sits between the entrants to the permanent collection and the opening touring show, Ocean Liners: Speed and Style, which tells the story of Scotland’s role in the golden age of cruise liners.

V&A Dundee’s director, Philip Long, said “it was with some emotion” that he was finally able to unveil the museum and that the challenges that beset the huge project had been overcome, more than a decade after it was originally proposed.

Another V&A director, Dr Tristram Hunt, said Ocean Liners: Speed and Style could “not be a more appropriate inaugural exhibition for Mr Kuma’s amphibious, semi-nautical, wonderful museum that is so successfully reconnecting the city with its historic waterfront”.

Dundee City Council leader John Alexander told invited guests to the first viewing of the museum that he felt a “tremendous sense of pride” in the building.

He said: “There’s a fire in the bellies of Dundonians that wasn’t there ten years ago. Dundee is leading the charge in cultural-led regeneration.”

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European Court, Government, Legal, Society

ECHR ruling: Intelligence agencies can harvest data

PERSONAL DATA COLLECTION

Controversial powers that have been used by British spies to hoover up vast amounts of personal information to help foil major terrorist plots do not automatically breach human rights, the European Court of Human Rights has ruled.

It said UK intelligence agencies could scoop up data belonging to millions of citizens if there were proper safeguards and supervision.

Judges said harvesting and storing data on the websites people visited, who they called, texted or emailed, and their medical, tax and financial records was not “in and of itself” unlawful.

The ruling will be a boost to the Government, which says collecting “bulk data” and communications information has been crucial in preventing jihadist plots.

Ministers brought in the Investigatory Powers Act last year to tighten up the UK’s use of sweeping surveillance powers and introduced new oversights.

However, the ECHR found that the previous spying regime – exposed by Edward Snowden’s revelations about intelligence techniques – did violate human rights.

In 2013, Mr Snowden revealed that GCHQ, the UK’s eavesdropping agency, had been secretly collecting communications sent over the internet on an industrial scale.

The ECHR judgment said the system did not have any proper safeguards because it led to completely “untargeted” collection of information.

It ruled this had violated Article 8 and Article 10 of the European Convention of Human Rights – safeguarding privacy and confidential journalistic material.

The court’s ruling related to the Regulation of Investigatory Powers Act which was replaced by the new Act at the start of 2017.

The court acknowledged that this act makes significant changes to the interception and communications data regimes, though critics call it a “turbocharged snoopers’ charter”.

The British Government has said it would give “careful consideration” to the ruling.

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