SCIENTIFIC RESEARCH

The arthritis gene responsible for the painful condition which manifests itself in worn down joints is being linked to the process of natural selection and evolution of mankind.
A single gene that made it easier for early humans to colonise Europe and Asia also causes arthritis, researchers claim.
The gene, which is known to cause people to be more compact, became more common when early humans moved out of Africa.
Being smaller helped humans cope with colder temperatures because it meant less body area to keep warm.
However, the down side is that someone with the gene is twice as likely to develop arthritis as someone without it.
The findings highlight the role that genetics plays in the painful condition – which is often thought of as a disease caused by ‘wear and tear’ on joints.
Around a half of all European and Asian people carry the gene, which is ‘relatively rare’ in most Africans.
Researchers at Stanford University School of Medicine and Harvard University said the gene ‘has been repeatedly favoured [by natural selection] as early humans migrated out of Africa and into colder northern climates.’
Dr David Kingsley, professor of developmental biology at Stanford, said: ‘Even though it only increases each person’s risk by less than twofold, it’s likely responsible for millions of cases of arthritis around the globe.
‘This study highlights the intersection between evolution and medicine in really interesting ways, and could help researchers learn more about the molecular causes of arthritis.’
A more compact body structure due to shorter bones could have helped our ancestors better withstand frostbite and reduce the risk of fracturing bones in falls while slipping on ice, the researchers speculate.
These advantages in dealing with chilly temperatures and icy surfaces may have outweighed the threat of osteoarthritis, which usually starts to occur after prime reproductive age.
Dr Kingsley added: ‘The gene we are studying shows strong signatures of positive selection in many human populations.’
The research was first published in the online journal Nature Genetics. The gene, known as GDF5, was first linked to the growth of bones in the early 1990s.
Researchers found a variant that is very common in Europeans and Asians but also rare in Africans.
- Recently in Science Questions of Science: Against the grain

Science-in-motion: a series of short articles following topics in science.
. Genetic modification
This refers to the use of modern biotechnology techniques to change the genes of an organism, altering the DNA that instructs its cells how to build proteins. Many crop plants are genetically engineered to possess desirable traits such as resistance to pests or harsh environments.
In traditional breeding of crops and livestock, farmers pick plants or animals with desirable traits and crossbreed them to create commercially valuable offspring. Genetic modification allows the traits of organisms to be altered in ways that are not possible through traditional breeding.
For example, some cotton plants are modified to carry a gene from soil bacteria. This makes them produce a chemical that kills insect pests, reducing the need for pesticides. Sometimes, genetic modification turns down or ‘silences’ the activity of genes that an organism already has. This can prevent oilseed rape crops producing unhealthy oils, for instance. Genetically modified animals are often used in experiments to study gene functions, but are not yet bred for commercial agriculture.


