Category Archives: Research

Government, Health, Medical, Research, Science, Society

Health risk for women in their 30s who do not exercise…

HEART RISK

A major study has found that a lack of exercise puts younger women at far greater risk of heart attacks than smoking or being obese.

Researchers found inactive women in their 30s are almost 50 per cent more likely to develop heart disease in their lifetime than those who are fit.

The team has now called on governments to launch public health campaigns on the importance of exercise, arguing it would have a far greater impact on reducing heart disease deaths than drives to discourage smoking or promote healthy eating.

The scientists looked at the records of 32,541 women aged 22 to 90, including details about lifestyle and whether they had heart disease. Armed with this data, they used a mathematical formula to work out their risk of heart disease during their lifetime based on whether they were inactive, were smokers, had hypertension (high blood pressure) or were obese.

A lack of exercise was found to pose the greatest risk to women across all age groups.

Those in their early 30s who were classed as inactive were nearly 50 per cent more likely to suffer from the condition in their lifetime than active women.

The risk decreased slightly with age. Inactive women in their late 40s were 38 per cent more at risk, falling to 28 per cent in the late 50s.

By comparison, the risk was 40 per cent for women smokers in their 30s and 30 per cent for the obese. Although obesity and being unfit are closely linked, the researchers from the University of Queensland pointed out that many slim women are inactive.

The latest UK figures show a quarter of women are classified as inactive, while just over half do the recommended two and a half hours of physical activity a week.

Heart disease, which includes heart attacks and strokes, is by far the biggest killer in Britain, claiming 82,000 lives a year.

Experts have previously claimed that exercising can halve the risk of getting the condition because it lowers the blood pressure, reduces cholesterol which blocks arteries, and improves circulation.

Professor Wendy Brown, one of the team’s lead researchers, described inactivity as the ‘Cinderella risk factor’ for heart disease. She said: ‘Our data suggests that national programmes for the promotion and maintenance of physical activity across the adult lifespan, but especially in young adulthood, deserve to be a much higher public health priority for women than they are now.’

The study’s findings, first published in the British Journal of Sports Medicine, concluded: ‘Continuing efforts to reduce smoking rates in young adult women are warranted… however, from about age 30, the population attributable risk for inactivity outweighs that of the other leading risk factors, including high Body Mass Index, which is currently receiving much more attention.’

A spokesperson for the British Heart Foundation, said: ‘We already know physical inactivity is a major risk factor for heart disease. Interestingly, this study shows its dominant influence on heart disease amongst women, and suggests a greater need to promote regular physical activity… It is important to remember that heart disease is linked to other factors such as smoking, obesity, high blood pressure and high cholesterol.’

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Government, Health, Medical, Research, Science, Scotland, Society

Scottish scientists in a breakthrough bid to find a vaccine for malaria…

MALARIA VACCINE

Scientists in Scotland trying to produce a vaccine for malaria have successfully tested a prototype on mice.

Researchers at Edinburgh University found that their vaccine enabled the immune system to produce antibodies which responded to the human malaria parasite.

Mosquito-borne malaria kills around 600,000 people around the world each year and many forms of the disease are becoming resistant to existing drugs.

A successful vaccine is difficult to produce as it must contain proteins which are present in the malaria parasite in order for the immune system to produce antibodies.

Malaria proteins, however, have a complex chemical structure, which is difficult to reproduce in a laboratory.

Despite that, scientists in Edinburgh have managed to grow them inside a tiny single-celled aquatic creature.

It’s hoped the technique will not only make a vaccine possible but easy to produce, as the creature can multiply quickly.

The team leader, Dr David Cavanagh, from the immunology department at Edinburgh University, said:

… There is a desperate need for an effective vaccine which can be made easily in large quantities.

He added:

… Our findings meet this challenge and, with more work, could lead to a vaccine to help those most at risk.

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Health, Medical, Research, Science, Scotland, Society

A breakthrough treatment in beating superbugs…

GALLIUM

Scottish scientists may have discovered a ‘silver bullet’ in winning the war against infection.

For some time now it has been feared that antibiotics are becoming increasingly powerless in the face of lethal bacteria which are developing resistance to the drugs.

The latest breakthrough, however, suggests that a revolutionary new treatment could turn the tide.

Scientists and researchers from the Universities of Edinburgh and Zurich, in Switzerland, found that germs are not only killed off by the element gallium but that they also struggle to evolve into resistant strains.

In tests carried out, the metal was pared against a highly-resistant bacterium commonly found in hospitals which can cause pneumonia and septic shock.

The researchers noted that the bug continued to multiply when faced with antibiotics but stalled when it came up against gallium.

Scientists also found that three-quarters of infected moth larvae survived when given the treatment compared with only 5 per cent of those which went without.

The study states: ‘Crucially, while resistance soon evolved against conventional antibiotic treatments, gallium treatments retained their efficacy over time.’

It adds: ‘In light of our results, we contend that this approach could curb microbial virulence… and therefore represents a promising alternative to our dwindling succession of traditional antibiotics.’

The team behind the research said they hoped their work would lead to a new breed of drugs.

The team’s lead author, Dr Adin Ross-Gillespie, said:

… It’s crucial that alternatives to antibiotics are found. Humanity is facing what has been described as a catastrophic threat: conventional antibiotics are losing efficacy due to the worldwide rise and spread of multi-drug resistant bacteria and very few new antibiotics are on the horizon.

The key to gallium’s success is its chemical similarity to iron, which bacteria cells need to flourish.

They send out molecules, called siderophores, which search for and track down the essential nutrient.

These are then tricked into binding with gallium instead. As the cells become starved of iron, they dispatch even more siderophores, a process which eventually wears them out.

Gallium’s subtler approach limits the chances of a resistant strain evolving. Unlike antibiotics, it works outside of the cell so the odds are slim of a mutation which survives and then evolves further.

Last year, Scotland’s chief medical officer, Sir Harry Burns, wrote to all health boards in Scotland warning of increasing numbers of bugs resistant to the most powerful antibiotics. There was only one such case in 2007, but 25 cases in 2012.

ABOUT GALLIUM:

Gallium is a soft, silvery metal which forms a brittle solid at lower temperatures.

The heat of a human hand is enough to convert it into a shiny liquid that at first glance resembles mercury. This is because the melting point is usually low for a metal, being about 29.76c – only a few degrees above the usual room temperature of about 21c.

Gallium was first isolated in its elemental form in 1875 by French scientist Paul Emile Lecoq de Boisbaudran, who named it after the Latin name for his homeland, Gallia.

Despite its ability to interfere with cells’ uptake of iron, gallium is not normally considered toxic in low doses.

 

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