Nature, Research, Science

Arthritis gene linked to colonisation and spread of mankind

SCIENTIFIC RESEARCH

Arthritis Gene

The arthritis gene responsible for the painful condition which manifests itself in worn down joints is being linked to the process of natural selection and evolution of mankind.

A single gene that made it easier for early humans to colonise Europe and Asia also causes arthritis, researchers claim.

The gene, which is known to cause people to be more compact, became more common when early humans moved out of Africa.

Being smaller helped humans cope with colder temperatures because it meant less body area to keep warm.

However, the down side is that someone with the gene is twice as likely to develop arthritis as someone without it.

The findings highlight the role that genetics plays in the painful condition – which is often thought of as a disease caused by ‘wear and tear’ on joints.

Around a half of all European and Asian people carry the gene, which is ‘relatively rare’ in most Africans.

Researchers at Stanford University School of Medicine and Harvard University said the gene ‘has been repeatedly favoured [by natural selection] as early humans migrated out of Africa and into colder northern climates.’

Dr David Kingsley, professor of developmental biology at Stanford, said: ‘Even though it only increases each person’s risk by less than twofold, it’s likely responsible for millions of cases of arthritis around the globe.

‘This study highlights the intersection between evolution and medicine in really interesting ways, and could help researchers learn more about the molecular causes of arthritis.’

A more compact body structure due to shorter bones could have helped our ancestors better withstand frostbite and reduce the risk of fracturing bones in falls while slipping on ice, the researchers speculate.

These advantages in dealing with chilly temperatures and icy surfaces may have outweighed the threat of osteoarthritis, which usually starts to occur after prime reproductive age.

Dr Kingsley added: ‘The gene we are studying shows strong signatures of positive selection in many human populations.’

The research was first published in the online journal Nature Genetics. The gene, known as GDF5, was first linked to the growth of bones in the early 1990s.

Researchers found a variant that is very common in Europeans and Asians but also rare in Africans.


Science in motion

Science-in-motion: a series of short articles following topics in science.

. Genetic modification  

This refers to the use of modern biotechnology techniques to change the genes of an organism, altering the DNA that instructs its cells how to build proteins. Many crop plants are genetically engineered to possess desirable traits such as resistance to pests or harsh environments.

In traditional breeding of crops and livestock, farmers pick plants or animals with desirable traits and crossbreed them to create commercially valuable offspring. Genetic modification allows the traits of organisms to be altered in ways that are not possible through traditional breeding.

For example, some cotton plants are modified to carry a gene from soil bacteria. This makes them produce a chemical that kills insect pests, reducing the need for pesticides. Sometimes, genetic modification turns down or ‘silences’ the activity of genes that an organism already has. This can prevent oilseed rape crops producing unhealthy oils, for instance. Genetically modified animals are often used in experiments to study gene functions, but are not yet bred for commercial agriculture.

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Education, Environment, Science

Questions of Science: Against the grain

SAND PARTICLE DEPOSITION

Sand particles on a beach or dunes seem to reach a certain grain size and then reduce no further. After millions of years, shouldn’t most sand have become dust?

THE GRAINS that we see in desert sand dunes have been deposited mainly by wind action. These will generally have originated in other parts of the desert where there are bare rock surfaces that are constantly being weathered by exposure to the sun, wind and water – the last of which is a surprisingly powerful weathering agent in deserts.

The result is a build-up of fragments of various sizes: boulders, pebbles, sand grains and dust. The last two, being smaller, can be removed by the wind and transported hundreds of kilometres, either in suspension high in the atmosphere, or by saltation – the process of bouncing along the ground.

The maximum grain size that can be transported by the wind is proportional to the wind speed – faster winds will move larger particles. This means that the large particles are deposited when and where the wind speed drops, which is often in low or flat terrain. So sand grains of around a certain size can accumulate in great masses in lowland basins, while the smaller fragments can be carried further; dust from the Sahara Desert quite frequently falls on the UK, for example. The result is that dunes are made up of grains mainly of the same size.

Similar principles apply on beaches, although the movement of particles is also affected by a variety of additional processes such as wave action, tides, offshore currents and long-shore drift – sand creep caused by waves approaching the beach obliquely. How effective each mechanism is at moving particles depends on its energy, so each will deposit particles in a different location. For example, wave action can sought beach material so that shingle will accumulate as a ridge high up the beach, while sand will only be exposed at low tide. Or long-shore drift may carry sand to one end of a beach, leaving shingle at the other.

Of course, all these fragments – boulders pebbles and sand – may gradually be broken down into finer particles, so that we might suppose all of the world’s rocks should by now have been reduced to a mass of dust blanketing the continents. But this does not happen because deposits of sand and dust gradually get compressed and cemented together to form new rock – the sandstones and mudstones. Nor does the planet run out of sand and dust, because bare rock surfaces are constantly exposed to weathering processes, and there will always be new rock exposed as a result of tectonic movement.

National Geographic

IF the sand in a coastal system is too fine relative to the energy of the waves then it will stay in suspension in the water and will not be deposited. So for a beach of dust to exist, the environment would have to be profoundly calm, and the dust-like sand would have to be kept wet in order to prevent the wind from claiming it. Most beaches are not like this.

Dunes are deposits of wind-blown sand, and for the sand to be deposited the size of the grains must exceed the carrying capacity of the wind. Sand dunes are innately dry places and there is no way that dust-sized particles could hope to stay put in these areas, however weak the wind may be.

Desert dunes exist in gigantic systems, whereas beach dunes form only a narrow band running along the back of some sea beaches, and are created by gusts from the sea that transport sand up from the beach. Yet both systems result from the same key processes of wind-borne matter being deposited when the wind becomes too weak to keep it aloft. Of course, even the tiniest sand grains will be deposited somewhere, but they will be highly dispersed and will not form dunes.

. You may also like  Skimming pebbles on water. But how does it happen?

 

. Appendage:

Sand


 

Science in motion

Science-in-motion: a series of short articles following topics in science.

. Newtonian gravity

Isaac Newton’s law of universal gravitation, published in 1687, was the first clear mathematical description of how bodies such as planets and stars attract each other under their mutual gravitational pull.

Newton’s inspiration for the theory came from watching an apple falling from a tree. A falling apple accelerates towards the ground, so Newton reasoned from his laws of motion that there must be a force, which he called gravity, acting on the apple. This force might have a huge range and could also be responsible for the orbit of the Moon around the Earth, if the Moon had just the right speed to remain in orbit despite constantly ‘falling’ towards the Earth.

He went on to show that the gravitational force between two massive objects is directly proportional to the product of their masses and weakens with the square of the distance between them. But troubling, the theory didn’t explain why the force was transmitted across empty space. This problem is resolved in Einstein’s general relativity theory.

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Medical, Research, Science

An influenza patch that can replace the annual flu jab

MEDICAL SCIENCE

A PATCH could replace the annual flu jab, research suggests.

In future, the patches could be sent out in the post, enabling people to quickly and easily vaccinate themselves without having to queue at the GPs surgery, experts have said.

A trial of the patch by US scientists at Emory University in Atlanta, Georgia, found it worked as well as a jab and was preferred by patients.

The study, published this week in the Lancet medical journal, also revealed it could be safely stored for a year without a fridge – meaning it could easily be distributed to patients to administer to themselves.

The device, measuring roughly one inch in diameter, contains the same vaccine as is given in conventional flu injections.

But it can be self-administered by simply placing on the wrist for 20 minutes and then removed.

The patch contains 100 tiny ‘microneedles’ which pierce the top layer of the skin.

The needles dissolve while they are in the skin, meaning there is no danger of piercing a second patient and passing on bloodborne diseases – a major safety fear when people inject themselves without professional medical supervision.

Experts said the device could significantly improve uptake of the flu vaccination.

The disease kills 5,000 people in England each year, and the vast majority of victims are elderly or suffer from existing respiratory conditions.

For this reason, the NHS encourages anyone over the age of 65 to have an annual influenza jab.

Younger people who are considered at risk – including all pregnant women, young children aged two, three and four, and anyone with asthma or other conditions – are also offered the vaccine.

However, uptake of the jab is poor, and falling. Only 71 per cent of over-65s had the vaccine in 2015/16, along with just 42 per cent of pregnant women, roughly a third of young children, and less than half of people with existing health conditions.

Experts said alternative ways of delivering the vaccine might improve take-up – particularly among those afraid of needles or too busy to go to the GP.

Researchers tested the patch on 100 people who had chosen not to receive the flu vaccine.

They found that after six months, no serious side effects linked to the vaccine were reported and there were no cases of influenza.

As well as this, participants reported high ‘acceptability’ scores of between 4.5 and 4.8 out of five, with some 70 per cent saying they preferred it to the injection.

Study leader Dr Nadine Rouphael said: ‘Despite the recommendations for adults and children to receive a flu shot, many people remain unvaccinated. The patch could be safely applied by participants themselves, meaning we could envisage vaccination at home, in the work place, or even via mail distribution.

‘These advantages could reduce the cost of the flu vaccine and potentially increase coverage.

‘Our findings now need confirming in larger trials.’

Experts in Britain welcomed the study, saying the patches could be particularly useful for children.

Dr Maria Zambon, director of reference microbiology at Public Health England, said: ‘This is a good early research and we await more tests on these patches to see their effectiveness.

‘Microneedle patches have the potential to be used for vaccination programmes and could help people scared of needles.’

Appendage:

Flu Patch (2)

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