Britain, Health, Medical, Research, Science

Findings suggest the use of pomegranate could halt Alzheimer’s…

MEDICAL RESEARCH

British scientists have said that pomegranates could help stop the progression of Alzheimer’s disease, a debilitating illness of the brain.

They claim a chemical compound in the fruit could prevent inflammation which destroys brain cells.

The findings raise hope that punicalagin could now be used in a drug to prevent or treat the condition, while the hunt for a cure continues. Treatments could also benefit sufferers of rheumatoid arthritis and Parkinson’s disease in the future, because any resulting drug could help to combat inflammation involved in these conditions too.

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Pomegranates have been used for centuries in Middle Eastern folk medicine and are said to be effective against heart disease, high blood pressure (hypertension), and some cancers, including prostate. The breakthrough shows that punicalagin can inhibit inflammation in specialised brain cells known as micrologia. This inflammation triggers the destruction of brain cells, which makes Alzheimer’s progressively worse.

Researchers at the University of Huddersfield along with colleagues at the University of Freiburg in Germany used brain cells from rats to test their findings.

Study leader Dr Olumayokun Olajide, of Huddersfield’s Department of Pharmacy, is now looking into how much pomegranate extract would be effective in a drug. He pointed out that juice products which are 100 per cent pomegranate contain approximately 3.4 per cent punicalagin. Most of the antioxidant compounds are found in the outer skin of the fruit.

Dr Olajide, added: ‘We do know that regular intake and regular consumption of pomegranate has a lot of health benefits – including prevention of neuro-inflammation related to dementia.’

Although the link has yet to be scientifically proven, pomegranate may be useful for treating inflammation in other conditions such as rheumatoid arthritis, Parkinson’s and cancer, not just neuro-inflammation of the brain.

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Arts, Books, Psychology, Science

Book Review – ‘Headhunters: The Search For A Science Of The Mind’

EVOLUTIONARY PSYCHOLOGY

IN March 1898, a group of scientists set sail from London for the Torres Straits between Australia and New Guinea. The purpose of their embarkation was to study local islanders in the hope that they would learn important lessons about the way the human brain works.

Equipped with various colour photographs and some ‘footer shirts’, the researchers were confident these would prove irresistible to the natives.

For the following 15 months or so, they conducted a series of tests – one scientist would measure people’s sight, another hearing, another skin sensitivity, and so on. On their return to London, the team presented their findings to the British Association For The Advancement Of Science.

The exercise was a total disaster. Far from showing any major differences between the way in which a Bornean tribesman perceived the world and, say how a Cambridge academic did, their tests revealed almost no variations at all. The Association believed that only one conclusion could be drawn: the tests had been hopelessly botched. As a result the scientists’ efforts were poo-poohed with their reputations smeared and blackened.

Over the next few years, though, doubts began to creep in. Maybe the fact that there were no key differences between people’s senses wasn’t actually a blunder after all, but rather a discovery of huge significance and relevance. Viewed from the aspect that, far from being a human evolutionary ladder – as was generally accepted – in which the British stood at the top with everyone else on the lower rungs, maybe the inference implied by the group was that we were all essentially the same.

With their reputations restored, the scientists set out once again, and were eager to find out and track how the human brain developed in the way that it did. Originally, smell was by far the dominant sense, but as mammals began to evolve such as when they began to live in trees, sight, sound and taste surged to the fore.

The difficult part, as far as the scientists were concerned, was how to measure things that seemed to defy analysis – like pain or the way people react to stress.

One of the members of the original expedition, a psychologist called William Rivers, conducted a series of experiments with a fledgling neurologist. The two men would sit in the neurologist’s rooms in Cambridge, with Rivers pulling out the hairs of his fellow researcher and sticking needles into various parts of his body. The results were recorded.

Not surprisingly, the neurologist found that he could work for only an hour at a time before he started to feel a bit queasy. In between sessions, the two men would engage in bursts of vigorous exercise such as running or horse-riding. The results were encouraging, but what they really wanted was a kind of mass experiment in which large numbers of people could be subjected to the same trauma to see how they reacted. They didn’t have to wait long.

In August 1914, World War I was declared. Within months, Rivers and his fellow scientists were confronted with what amounted to the biggest laboratory on Earth.

A number of different aspects came under observation, but none interested them more than the effects of prolonged exposure to gunfire. Although it was another of the original expedition team members, Charles Myers, who coined the phrase ‘shell shock’, it was Rivers’s work at Craiglockhart Hospital near Edinburgh (where poets Siegfried Sassoon and Wilfred Owen were among his patients) that proved the most significant.

At first, Army doctors would label traumatised soldiers ‘Mental’, ‘Insane’ or even ‘GOK’ (‘God Only Knows’). But as the war went on and it became obvious that soldiers were not faking their symptoms, attitudes started to change and treatments started to improve.

Yet, the psychologists were still feeling their way in the dark. William McDougall, another researcher who had also set sail on the original expedition, treated a soldier called Percy Meek, who had been a basket-weaver in Norfolk before the war. As well as having severe shell shock, Meek was diagnosed as suffering from amnesia.

Under hypnosis, he revealed that he was visited every night by the ghost of a German soldier whom he had killed on the Marne in 1914.

After a while Meek stopped seeing the ghost, but his condition became even worse – his twitching became more pronounced, he lost the power of speech and spent all day playing with dolls. There is an astonishing archive film of him cowering in a wheelchair with a teddy bear on his knee.

McDougall was inclined to write him off as a helpless case, but then, in 1917, something extraordinary happened: Meek made a spontaneous recovery.

His memory and his speech came back, and within another year he was teaching basket-weaving to fellow patients – proof perhaps that the brain is even more complex and mysterious than McDougall and his colleagues had ever anticipated.

As Ben Shepherd proved with his critically acclaimed A War of Nerves: Soldiers And Psychiatrists 1914-1994, the author writes exceptionally well about how the mind functions under duress.

Shepherd’s account of how a small group of scientific researchers defied ridicule in their quest to learn how the brain works is as stirring as it is dramatic. Whilst it is clear from the narrative that he possesses a sharp eye for absurdity, there’s also a broad streak of sympathy that runs throughout.

It’s tempting to see Shepherd’s story as an illustration of how psychology has developed in this country. There may have been quite a few wrong turns as this science has developed, but eventually its pioneers steered a path through a fog of confusion to reach a greater understanding of who we are and how we got to be that way.

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Britain, Environment, Research, Science, Scotland

Rare beetle found in abundance…

MELOE BREVICOLLIS

A rare flightless beetle in Britain, thought to be close to extinction, has been found in abundance on a Hebridean island.

The short-necked oil beetle was thought to have disappeared completely until 2008, when scientific surveys uncovered two small populations in South Devon, and the Isle of Coll.

Researchers working for RSPB Scotland and charity Buglife have now found more than 150 of the threatened insects. This equates to a 400 per cent increase since the last count was made in 2010.

Scientists also identified two new sites on the island for the beetles, which rely on wild bees and their larvae to survive.

A spokesperson and natural recovery officer at RSPB Scotland, said:

… This was a beetle that was thought to be extinct for about 60 years… A small population was found in Devon and then, out of nowhere, about 20 individuals were discovered on Coll.

… To go back and find the species in such abundance now shows they are doing a lot better than we ever dreamt they could be.

The beetle – Latin name Meloe brevicollis – is named for the toxic oil secretions it produces when threatened.

A conservation officer at Buglife Scotland, said:

… The abundance of wildflowers in the machair and dunes of the island, combined with lots of warm, bare sand provide a near-perfect habitat for the solitary bees that the beetles depend on.

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