Biotechnology, Health, Medical, Research, Science

Cell transplant gives hope for treating blindness…

A MAJOR ADVANCE

Scientists in Britain have made a major leap forward in efforts to treat blindness.

They have grown part of an eye in the laboratory and have extracted the light-sensitive cells which are the key to vision.

These cells were injected into mice, where they seemed to grow normally and formed the crucial connections between the eye and brain.

Such developments could pave the way for a treatment which could eventually give millions back their sight. It is hoped the first human patients could be treated in as little as five years. Transplanting just a small number of cells could have a big impact on quality of life.

Those who could benefit include men and women with age-related macular degeneration – the most common cause of blindness in the elderly. This condition affects more than 600,000 Britons and the number is expected to triple in the next 25 years as the elderly population swells.

There are few treatments for the condition – and no cure.

The research and experimentation is being carried out at University College London in which scientists are trying to replace damaged cells in the retina, the light sensitive ‘film’ at the back of the eye.

Last year, researchers used healthy cells from young mice to restore vision in adult animals. The results were said to be ‘dramatic’, with the treated animals able to quickly find their way out of a miniature swimming pool in dim light, while untreated ones swam around in circles.

Stem Cell Therapy for Blindness

The project’s lead-scientist, Professor Robin Ali, said the results amount to a ‘major advance’. His team took embryonic stem cells – ‘master cells’ capable of turning into other cell types and widely touted as a repair kit for the body – and used a cocktail of nutrients to coax them into turning into a retina.

They then raided the laboratory-grown retina for rods (key cells which pick up light and send it to the brain for conversion into images). The rods were then transplanted into the eyes of mice.

A retina has been grown in a dish before but Professor Ali’s team are the first to transplant cells from one successfully.

The journal Nature Biotechnology was the first to report the findings and has said that the lab-grown cells integrated into the existing eye was successful in forming the nerve connections needed to send information to the brain.

Professor Ali said:

… We are getting closer and closer to carrying out a trial.

However, the need to be highly confident that the treatment is safe and effective means that widespread use is at least 10-15 years away.

The Medical Research Council, which funded the team’s work, said in a statement:

… This study is an important milestone on the road to developing a widely available cell therapy for blindness.

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Biotechnology, Britain, Environment, European Union, Government, Health, Research, Science, Technology

Genetically modified foods and technology – kick it into the long grass…

Despite deep public hostility in Britain, the UK Government is stepping up its campaign in favour of genetically modified foods. Masquerading as champions of progress and prosperity, ministers want European Union controls on GM produce to be drastically relaxed.

According to the Environment Secretary’s public relations spin, once these anachronistic restrictions are abolished and public scepticism and anxieties are overcome, then we will enter a brave new world of abundance.

The propaganda being put out by the UK Government remains hopelessly unconvincing. Far-fetched assertions and hyperbolic claims won’t feed the world, or protect our health. The hollowness of the ministerial case has been exposed with scientific argument as opposed to the Government’s flimsy, if not ridiculous claims, why the world needs genetically-modified foods. Owen Paterson’s assertions are nothing more than to promote the corporate profitability of elite biotech companies.

Paterson comes across as an ill-briefed, rather hysterical mouthpiece for the GM industry. He has tried to argue that science was on his side, yet he can only back up his arguments with outrageous emotional blackmail.

Melodramatic is one word that springs to mind. At one stage he argued that, without the acceptance of GM crops, young people in Asia ‘will go to bed blind and some will die’. Does Mr Paterson regard genetic modification as some kind of miracle cure?

Many will assume that Owen Paterson has resorted to such nonsense precisely because his case is so pitifully weak. GM technology is no panacea for the world’s ills. Even after almost two decades of its intensive use in large parts of the world, particularly the United States, there is scant evidence that it increases crop yields, assists global development or combats disease. The exact opposite is true.

There is now a growing amount of research demonstrating that genetic modification has the potential to cause serious health problems and widespread environmental degradation. Remaining sceptical is surely the right approach as we cannot be sure that GM food is safe to eat. Despite the scientific sophistication, genetic engineering remains a rather crude technique of manipulating biology.

The process involves moving genetic material across species barriers, which undoubtedly carries the risk of triggering unpredictable and irreversible changes in DNA, proteins and biochemical composition. It is radically different from all previous methods of improving plants and breeds.

The notion that such an approach can be completely safe is either dangerous wishful thinking, or a denial of reality motivated by vested commercial and political interests.

It is the pro-GM lobby who are seeking for the public to make a leap of faith. But as time has moved on, the case against genetic engineering becomes more persuasive.

Just this month, for instance, a report from Flinders University in Australia revealed that genetically modified food given to pigs may lead to severe stomach inflammations and far heavier uteruses, which can be an indicator of serious disease.

Some farmers claim that stomach inflammations and irritations can also lead to pigs becoming more aggressive. Farmers have reported that, for as long as GM crops have been in the food supply of animals, they have seen increasing digestive and reproductive problems in their livestock.

What is especially worrying is not that most of us eat pork, but that the digestive system of pigs is similar to that of humans.

The Australian report backs up other evidence about the health risks of GM technology. Studies on laboratory animals show that GM food can cause allergies and be toxic. Rats fed GM tomatoes, for instance, have developed stomach lesions, while new research from New Zealand has found that one GM wheat variety has the potential to cause liver disease.

Human health may also be threatened by the damage that genetic engineering inflicts on the balance of the environment’s delicate ecosystems. One of the most insidious aspects of genetic modification is that, contrary to the claims of being environmentally friendly, it actually encourages the aggressive use of herbicides.

The top-selling weedkiller glyphosate is marketed by the giant biotechnology company Monsanto as ‘Roundup’. This company is a leading campaigner for the relaxation of EU controls on genetic modification.

Monsanto has also developed a range of crops that are genetically resistant to glyphosate. This supposedly means that farmers can spray the herbicide over their land and kill all the weeds without damaging their crops.

Yet there is a real risk that the environment and the consumers could be the losers. Studies have shown that glyphosate leaves a dangerous residue on food, as well as leaching into the groundwater. Glyphosate exposure has been associated with birth defects, hormone imbalances, Parkinson’s disease and non-Hodgkin’s lymphoma, a type of blood cancer.

What is more, the excessive use of glyphosate appears to have promoted the evolution of a destructive breed of ‘superweeds’. No fewer than 24 glyphosate-resistant weed species have been identified since Roundup-tolerant GM crops were introduced in 1996. Tampering with nature is leading to unforeseen consequences.

The arguments put forward by the GM-lobby even falter on increases to production. Their promises of even-higher yields are unfounded. What usually happens with genetic modification is an initial series of good harvests, followed by a dramatic decline. A study published just last week showed that for the production of maize, soy beans, oil seed rape and cotton, European non-GM crops have significantly outperformed American GM crops.

Far from representing exciting modernity, the irony is that genetic modification is unworkable, bankrupt technology. There are far better ways of driving progress in agriculture.

Scientists at Britain’s National Institute of Agricultural Botany, for example, have used a non-GM, natural process involving pollen from wild grass to produce a stronger, and more productive form of wheat. Early studies show that the yield could go up by 30 per cent.

Other organic, non-GM success stories include drought-resistant maize, blight-resistant potatoes, and a new variety of African rice which is four times as productive as traditional types.

This is where the future should lie. Non-GM technology has real promise, whereas genetic engineering has brought only failure and frustration.

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Biotechnology, Britain, Economic, European Union, Government, Health, Science, Technology

Environment Secretary says GM farming would save the countryside…

The Environment Secretary, Owen Paterson MP, has controversially claimed that GM farming would save the countryside and cost less.

Mr Paterson says that Britain should lead the way in producing genetically-modified food because it would lower prices and free up the countryside.

A long standing advocate of GM technology, Mr Paterson claims its adoption in the UK could be as significant as the agricultural revolution.

He has pointed out that since 1996 there has been a hundred-fold increase in the use of GM crops around the world, with 17 million farmers in 28 countries now growing what critics have branded Frankenstein foods. Less than 0.1 per cent of this takes place in the EU.

According to Mr Paterson farmers wouldn’t grow these crops if they didn’t benefit from doing so. Governments wouldn’t license these technologies, he says, if they didn’t recognise the economic, environmental and public benefits. He also added that consumers wouldn’t buy these products if they didn’t think they were safe and cost-effective.

In a speech designed to appeal to traditionalists, he said that while the rest of the world is ploughing ahead and reaping the benefits of new technologies, Europe risks being left behind.

… The use of GM (technology) could be as transformative as the original agricultural revolution was. The UK should be at the forefront now, as it was then.

Mr Paterson says that GM farming can help feed people in poorer countries and inject missing vitamins into the diets of children in the UK. He also argued that using GM crops to improve yields will require less space, and will free up more greenfield land.

… If we use cultivated land more efficiently, we could free up space for biodiversity, nature and wilderness.

The Environment Secretary also promotes the view that GM crops can help combat the effects of Britain’s increasingly erratic climate.

In recent weeks, the Prime Minister, the Government’s chief scientific adviser, Sir Mark Walport, and the Science Minister, David Willetts, have all voiced support for GM crops.

Mr Paterson intends to lead a campaign among European ministers to make Brussels lift many of its restrictions on the use of GM technology.

The Minister of State says that he is conscious of those who need reassurance on this matter. He highlighted the need for government, industry and the scientific community of having a duty to the British public to reassure them that GM is a ‘safe, proven and beneficial innovation.’

But despite the assurances, the Soil Association has warned:

… We need farming that helps poorer African and Asian farmers produce food – not farming that helps (GM producers) Bayer, Syngenta and Monsanto produce profits.

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