Category Archives: Science

Health, Medical, Science

Menopause misery. HRT isn’t the only answer

HEALTH

DR MAX PEMBERTON, an NHS psychiatrist and medical doctor, wrote recently on the significant shift in many doctors’ attitude towards Hormone Replacement Therapy (HRT). For far too many years, peri- and post-menopausal women have to had to fight hard for their right to access this medication.

An increasing number of doctors are now open to the idea that prescribing HRT can have real benefits for their patients – and, undoubtedly, this has made a life-changing difference for many women. Even though some 13million women in the UK are going through the menopause, it is estimated that one in four have to visit their GP at least three times before getting appropriate treatment.

Last year, official draft guidelines were issued to GPs which said alternative treatments should be considered. These included talking therapies “alongside or as an alternative to” HRT to help reduce menopause symptoms such as insomnia, low mood, and hot flushes. These guidelines have now been revised with health officials backtracking after accusations of “medical misogyny” – the implication being that menopausal symptoms were “all in the mind”. The guidance issued by NICE now advises that HRT should be offered as the first line of treatment. Some may believe this a positive development, but Dr Pemberton is unsure.

The medic is known to be a keen fan of HRT and he has seen many patients’ lives transformed by it. But he goes on to say that HRT isn’t suitable for everyone and that talking therapies can help those women presenting with symptoms that have a psychological component.

Dr Pemberton says that many women talk about no longer feeling like themselves, a disconcerting sense of something having changed, a vague undercurrent of unease, despair, and discombobulation. Trying to address what causes this turmoil is far more complicated than simply a blip in hormone levels. And neither can it be explained away by a woman’s dissatisfaction with life and her sense of loss and malaise as a chemical reaction.

That’s not to say that hormones don’t play an important part. Medical professionals know that fluctuations in hormones can be responsible for low and poor mood.

Over the years, Dr Pemberton has seen far too many women struggling to cope and for whom HRT has been hugely beneficial – helping them, for instance, to manage anxiety caused by the menopause.

But the medic also believes there are other factors that contribute to a woman’s sense of losing herself. He points out that low mood and anxiety are a result of complex social and psychological factors, rather than simple biology.

Changes to the body, disrupted sleep, hot flushes, and so on, he says, can make any woman feel out of control and depressed.

Dr Pemberton documents and records other issues he’s heard women talk about – for example, erratic mood swings and out-of-character behaviour. There are stories of women having affairs, quitting their jobs, or leaving their husbands around the menopause.

While some would seek to blame this all on fluctuations in hormone levels, the evidence for this isn’t that compelling.

The clinician says it’s not at all clear that drops in oestrogen and progesterone, the female sex hormones that start to decline in menopause, are entirely responsible.

Rather, the medic believes that the menopause acts like a ticking clock. It suddenly makes women open their eyes and review their lives. Much of the trauma and emotional turmoil that besets many women as they navigate menopause isn’t the consequence of fluctuating hormones but of a re-evaluation of their life’ situation. For many, their sense of self and identity is closely bound up with their roles within their family, particularly those who are mothers, who may feel bereft at the prospect of an empty nest.

It is also a cruel aspect of the inequality between the sexes that women have to contend with a society that’s more judgmental about how woman age than men. For a lot of women in their 50s and 60s, they have given the best years of their lives to other people and their careers, and now they’re not sure why. A vast number of menopausal women now feel invisible.

Dr Pemberton has had many menopausal and post-menopausal women attending his clinics and hearing the sad story that they no longer feel like a woman.

It is here, he says, that these people would surely benefit from having the time and space to explore and discuss their feelings and situation. That’s where talking therapies can play a vital role for many who have become desperately unhappy.

In the opinion of Dr Max Pemberton, the answer to many complex problems precipitated by the menopause aren’t always going to be found in HRT pills, patches, and gels.

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Arts, History, Philosophy, Science

Quantum Leaps: John Dalton

1766–1844

FOR much of his life, the primary interest of John Dalton, an English Quaker, was the weather. Living in the notoriously wet country of Cumbria, he maintained a daily diary of meteorological occurrences from 1787 until his death, recording in total some 200,000 entries. It was, however, his development of atomic theory for which he is most remembered.

Different atoms – It was around the turn of the nineteenth century that Dalton started to formulate his theory. He had been undertaking experiments with gases, in particular on how soluble they were in water. A teacher by profession, who only practised science in his spare time, he had expected different gases would dissolve in water in the same way, but this was not the case. In trying to explain why, he speculated that perhaps the gases were composed of distinctly different “atoms”, or individual particles, which each had different masses. Of course, the idea of an atomic explanation of matter was not new, going way back to Democritus of Abdera (c. 460–370 BCE) in ancient Greece, but now Dalton had the discoveries of recent science to reinforce his theory. On further examination of his thesis, he realised that not only would it explain the different solubility of gases in water, but would also account for the “conservation of mass” observed during chemical reactions as well as the combinations into which elements apparently entered when forming compounds (because the atoms were simply “rearranging” themselves and not being created or destroyed).

Atomic theory – Dalton publicly outlined his support for this atomic theory in a lecture in 1803, although its complete explanation had to wait until his book of 1808 entitled A New System of Chemical Philosophy. Here, he summarised his beliefs based on key principles, including: atoms of the same element are identical; distinct elements have distinct atoms; atoms are neither created nor destroyed; everything is made up of atoms; a chemical change is simply the reshuffling of atoms; and compounds are made up of atoms from the relevant elements. In the same book he published a table of known atoms and their weights, although some of these were slightly wrong due to the crudeness of Dalton’s equipment, based on hydrogen having a mass of one. It was a basic framework for subsequent atomic tables, which are today based on carbon (having a mass of 12), rather than hydrogen. Dalton also erroneously assumed elements would combine in one-to-one ratios (for example, water being HO not H2O) as a base principle, only converting into “multiple proportions” (for example, from carbon monoxide, CO, to carbon dioxide, CO2) under certain conditions. Although scientific arguments over the validity of Dalton’s thesis would continue for decades, the foundations for the study of modern atomic theory had been laid and with ongoing refinement were gradually accepted.

Prior to atomic theory, Dalton had also made a number of other important discoveries and observations in the course of his work. These included his “law of partial pressures” of 1801, which stated that a blend of gases exerts pressure which is equivalent to the total of all the pressures each gas would wield if they were alone in the same volume as the entire mixture.

Dalton also explained that air was a blend of independent gases, not a compound. He was the first to publish the law later credited to and named after Jacques-Alexandre-César Charles (1746–1823). Although the Frenchman had been the first to articulate the law concerning the equal expansion of all gases when raised in equal increments of temperature, Dalton had discovered it independently and had been the first to publish.

Dalton also discovered the “dew point” and that the behaviour of water vapour is consistent with that of other gases, and hypothesised on the causes of the aurora borealis, the mysterious Northern Lights. His further meteorological observations included confirmation of the cause of rain being due to a fall in temperature not pressure.

Further achievements – John Dalton began teaching at his local school at the age of 12. Two years later, he and his elder brother purchased a school where they taught some 60 children.

His paper on colour blindness, which both he and his brother suffered from, and which was known as daltonism for a long while, was the first to be published on the condition. Dalton is also largely responsible for transferring meteorology from being an imprecise art on folklore to a real science.

Chronology  

. 1793 Meteorological Observations and Essays published

. 1801 Dalton states his Law of Partial Pressure

. 1803 Outlines his atomic theory in a lecture. This transformed the basics of chemistry and physics

. 1808 A New System of Chemical Philosophy published.

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Arts, Science, Scotland

The life of Professor Peter Higgs

PIONEERING SCIENTIST

A SCIENTIST who achieved worldwide fame with the discovery of the so-called God Particle has died at the age of 94.

A statement from Edinburgh University, with which the scientist had a strong connection throughout his career, said that Professor Peter Higgs died “peacefully” at his home following a short illness.

The physicist, who had lived in the Scottish capital for more than 50 years, won the highly prestigious Nobel Prize in 2013 after he predicted the existence of an elusive fundamental particle – which would become known as the Higgs boson.

In 1964, he was one of the scientists who first proposed the existence of the sub-atomic particle that gives substance or mass to planets, stars, and life.

Paying tribute, Professor Sir Peter Mathieson, principal and vice-chancellor of the University of Edinburgh, said: “Peter Higgs was a remarkable individual – a truly gifted scientist whose vision and imagination have enriched our knowledge of the world that surrounds us. His pioneering work has motivated thousands of scientists, and his legacy will continue to inspire many more for generations to come.”

Fellow physicist Professor Brian Cox posted on social media: “I was fortunate enough to meet him several times, and beyond being a famous physicist – I think to his embarrassment at times – he was always charming and modest. His name will be remembered as long as we do physics in the form of the Higgs boson.”

Alan Barr, professor of physics at the University of Oxford, said: “From the mind of Professor Higgs came ideas which have had a profound impact on our understanding of the universe, of matter, and mass.”

He added: “He was also a true gentleman, humble and polite, always giving due credit to others, and gently encouraging future generations of scientists and scholars.”

Sir Ian Blatchford, chief executive of the Science Museum Group, said Professor Higgs was a “brilliant scientist who helped us to understand the fundamental building blocks of our universe”.

Born in Newcastle in 1929, Professor Higgs was the son of a BBC sound engineer.

His family later moved to Bristol where he attended Cotham Grammar School before going on to read theoretical physics at King’s College London. A five-decade-long career began when he graduated with a first-class honours degree in 1950.

Professor Higgs held research fellowships in Edinburgh and London before becoming a lecturer in mathematical physics at the University of Edinburgh in 1960. He wrote his ground-breaking paper after developing the theory while walking in the hills around the city.

In 1980, he became a professor of theoretical physics in Edinburgh, a post he held for 16 years before retiring and assuming the title of emeritus professor.

Outside academia, Professor Higgs married an American linguist, Jody Williamson. The couple had two sons, Christopher and Jonathan, before their divorce in the early 1970s.

The existence of the Higgs boson was proven in 2012 with use of the Large Hadron Collider (LHC) by a team from the European nuclear research facility in Geneva. Professor Peter Higgs was awarded the Nobel Prize along with Belgian Francois Englert for their work on the theory of the particle. At the time he said: “It’s very nice to be right sometimes.”

Despite the accolades he received – including more than ten honorary degrees – he said he felt uncomfortable being likened to other Nobel winners such as Albert Einstein.

Professor Higgs turned down the offer of a knighthood from Tony Blair in November 1999 as he did not want any title.

He lived in a small flat in Edinburgh, had no television, and used public transport. In later years, he told of his unease with the attention his achievement garnered, saying he was often bombarded by requests for selfies and could not walk the streets of Edinburgh without being stopped by fans.

The world is indebted to Professor Peter Higgs. May he rest in peace.

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